ArticleNeurology. Clinical practice2024
Therapeutic Responses to Efgartigimod for Generalized Myasthenia Gravis in Japan.
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Article in Neurology. Clinical practice, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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26citing papers in PubMed, 1 pooled it
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Effectiveness and safety of efgartigimod in myasthenia gravis: A meta-analysis of different antibody subtypes.Immunologic research · 2026Pooled it
- ADAPT NXT: Fixed Cycles or Every-Other-Week IV Efgartigimod in Generalized Myasthenia Gravis.Annals of clinical and translational neurology · 2025Trial
- Maintenance of Minimal Manifestation Status with Individualized-Interval Efgartigimod in Generalized Myasthenia Gravis: Study Protocol for a Single-Arm, Open-Label Clinical Trial.Neurology and therapy · 2026Article
- Steroid-Sparing Effect of Efgartigimod in Generalized Myasthenia Gravis: Study Protocol for a Single-Arm, Open-Label Clinical Trial.Neurology and therapy · 2026Article
- Patient Perceptions of Needs and Expectations Regarding the Current Management of Myasthenia Gravis: A Biopsychosocial Study.Neurology and therapy · 2026Article
- Italian recommendations for the diagnosis and treatment of myasthenia gravis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Clinical Impact of High-Dose Corticosteroids on Healthcare Resource Utilization and Steroid-Related Complications in Patients with Myasthenia Gravis in Japan.Neurology and therapy · 2026Article
- Assessing efgartigimod dosing patterns and Myasthenia Gravis Activities of Daily Living outcomes in clinical practice: results from a large patient support program database.Frontiers in neurology · 2026Article
- Development and External Validation of a Multivariable Model to Predict Early Minimal Symptom Expression Response in Adult Generalized Myasthenia Gravis Patients Treated With Efgartigimod.CNS neuroscience & therapeutics · 2026Article
- Efgartigimod for Generalized Myasthenia Gravis and Beyond: A Narrative Review of Its Pharmacological Profile, Clinical Utility, and Expanding Applications.Biomedicines · 2025Review
- Factors associated with early response to efgartigimod in patients with generalized myasthenia gravis: a multicenter retrospective observational study.Journal of neurology · 2025Observational
- Efgartigimod improves non-AChR generalized Myasthenia Gravis: a real world experience.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Real-World Experience with FcRn Inhibitors Efgartigimod and Rozanolixizumab in Myasthenia Gravis: Administration in Multiple Cycles and Transition from Intravenous to Subcutaneous Formulation.Neurology and therapy · 2025Article
- C5 complement inhibition versus FcRn modulation in generalised myasthenia gravis.Journal of neurology, neurosurgery, and psychiatry · 2025Observational
- Individualized Dosing of Efgartigimod in Patients With Generalized Myasthenia Gravis: Clinical Experience at a Single Center.Muscle & nerve · 2025Article
- Efgartigimod for induction and maintenance therapy in muscle-specific kinase myasthenia gravis.Therapeutic advances in neurological disorders · 2025Article
- Patterns and predictors of therapeutic response to efgartigimod in acetylcholine receptor-antibody generalized myasthenia gravis subtypes.Therapeutic advances in neurological disorders · 2025Article
- Efgartigimod for generalized myasthenia gravis in the extreme elderly (≥80 years): a multicenter retrospective real-world study.Frontiers in immunology · 2025Article
- Efgartigimod combined with rituximab helps improve the symptoms and reduce the use of corticosteroids in patients with MuSK antibody-positive MG: a single case report.Frontiers in immunology · 2025Article
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Authors and funding
19 authors at 1 institution in 1 country.
Shigeaki SuzukiDepartment of Neurology (SS, KI, DT), Keio University School of Medicine, Tokyo; Department of Neurology (AU, HH, MY), Graduate School of Medicine, Chiba University; Department of Neurology (YN, KU), Hanamaki General Hospital; Department of Neurology (MM), Tokyo Medical University; Department of Neurology (SK), Toho University Ohashi Medical Center, Tokyo; Division of Health Sciences (T. Kubota, MPT), Department of Clinical Laboratory and Biomedical Sciences, Osaka University Graduate School of Medicine; Department of Neurology (MS), Kindai University Faculty of Medicine, Sayama; Department of Neurology (NK), Neurology Chiba Clinic; Department of Neurology (T. Kimura), Hyogo Medical University, Nishinomiya; Department of Neurology (YS), National Hospital Organization Sendai Medical Center, Sendai; Department of Clinical Neuroscience and Therapeutics (TS), Hiroshima University; Department of Neurology (NM), National Hospital Organization Hokkaido Medical Center, Sapporo; and Department of Neurology (HM), International University of Health and Welfare, Narita, Japan.ORCID https://orcid.org/0000-0003-4388-4574
Akiyuki UzawaDepartment of Neurology (SS, KI, DT), Keio University School of Medicine, Tokyo; Department of Neurology (AU, HH, MY), Graduate School of Medicine, Chiba University; Department of Neurology (YN, KU), Hanamaki General Hospital; Department of Neurology (MM), Tokyo Medical University; Department of Neurology (SK), Toho University Ohashi Medical Center, Tokyo; Division of Health Sciences (T. Kubota, MPT), Department of Clinical Laboratory and Biomedical Sciences, Osaka University Graduate School of Medicine; Department of Neurology (MS), Kindai University Faculty of Medicine, Sayama; Department of Neurology (NK), Neurology Chiba Clinic; Department of Neurology (T. Kimura), Hyogo Medical University, Nishinomiya; Department of Neurology (YS), National Hospital Organization Sendai Medical Center, Sendai; Department of Clinical Neuroscience and Therapeutics (TS), Hiroshima University; Department of Neurology (NM), National Hospital Organization Hokkaido Medical Center, Sapporo; and Department of Neurology (HM), International University of Health and Welfare, Narita, Japan.ORCID https://orcid.org/0000-0001-9252-1863
Yuriko NaganeDepartment of Neurology (SS, KI, DT), Keio University School of Medicine, Tokyo; Department of Neurology (AU, HH, MY), Graduate School of Medicine, Chiba University; Department of Neurology (YN, KU), Hanamaki General Hospital; Department of Neurology (MM), Tokyo Medical University; Department of Neurology (SK), Toho University Ohashi Medical Center, Tokyo; Division of Health Sciences (T. Kubota, MPT), Department of Clinical Laboratory and Biomedical Sciences, Osaka University Graduate School of Medicine; Department of Neurology (MS), Kindai University Faculty of Medicine, Sayama; Department of Neurology (NK), Neurology Chiba Clinic; Department of Neurology (T. Kimura), Hyogo Medical University, Nishinomiya; Department of Neurology (YS), National Hospital Organization Sendai Medical Center, Sendai; Department of Clinical Neuroscience and Therapeutics (TS), Hiroshima University; Department of Neurology (NM), National Hospital Organization Hokkaido Medical Center, Sapporo; and Department of Neurology (HM), International University of Health and Welfare, Narita, Japan.ORCID https://orcid.org/0000-0003-2464-8947
Masayuki MasudaDepartment of Neurology (SS, KI, DT), Keio University School of Medicine, Tokyo; Department of Neurology (AU, HH, MY), Graduate School of Medicine, Chiba University; Department of Neurology (YN, KU), Hanamaki General Hospital; Department of Neurology (MM), Tokyo Medical University; Department of Neurology (SK), Toho University Ohashi Medical Center, Tokyo; Division of Health Sciences (T. Kubota, MPT), Department of Clinical Laboratory and Biomedical Sciences, Osaka University Graduate School of Medicine; Department of Neurology (MS), Kindai University Faculty of Medicine, Sayama; Department of Neurology (NK), Neurology Chiba Clinic; Department of Neurology (T. Kimura), Hyogo Medical University, Nishinomiya; Department of Neurology (YS), National Hospital Organization Sendai Medical Center, Sendai; Department of Clinical Neuroscience and Therapeutics (TS), Hiroshima University; Department of Neurology (NM), National Hospital Organization Hokkaido Medical Center, Sapporo; and Department of Neurology (HM), International University of Health and Welfare, Narita, Japan.ORCID https://orcid.org/0000-0002-6175-8902
Shingo KonnoDepartment of Neurology (SS, KI, DT), Keio University School of Medicine, Tokyo; Department of Neurology (AU, HH, MY), Graduate School of Medicine, Chiba University; Department of Neurology (YN, KU), Hanamaki General Hospital; Department of Neurology (MM), Tokyo Medical University; Department of Neurology (SK), Toho University Ohashi Medical Center, Tokyo; Division of Health Sciences (T. Kubota, MPT), Department of Clinical Laboratory and Biomedical Sciences, Osaka University Graduate School of Medicine; Department of Neurology (MS), Kindai University Faculty of Medicine, Sayama; Department of Neurology (NK), Neurology Chiba Clinic; Department of Neurology (T. Kimura), Hyogo Medical University, Nishinomiya; Department of Neurology (YS), National Hospital Organization Sendai Medical Center, Sendai; Department of Clinical Neuroscience and Therapeutics (TS), Hiroshima University; Department of Neurology (NM), National Hospital Organization Hokkaido Medical Center, Sapporo; and Department of Neurology (HM), International University of Health and Welfare, Narita, Japan.ORCID https://orcid.org/0000-0002-8731-0663
Tomoya KubotaDepartment of Neurology (SS, KI, DT), Keio University School of Medicine, Tokyo; Department of Neurology (AU, HH, MY), Graduate School of Medicine, Chiba University; Department of Neurology (YN, KU), Hanamaki General Hospital; Department of Neurology (MM), Tokyo Medical University; Department of Neurology (SK), Toho University Ohashi Medical Center, Tokyo; Division of Health Sciences (T. Kubota, MPT), Department of Clinical Laboratory and Biomedical Sciences, Osaka University Graduate School of Medicine; Department of Neurology (MS), Kindai University Faculty of Medicine, Sayama; Department of Neurology (NK), Neurology Chiba Clinic; Department of Neurology (T. Kimura), Hyogo Medical University, Nishinomiya; Department of Neurology (YS), National Hospital Organization Sendai Medical Center, Sendai; Department of Clinical Neuroscience and Therapeutics (TS), Hiroshima University; Department of Neurology (NM), National Hospital Organization Hokkaido Medical Center, Sapporo; and Department of Neurology (HM), International University of Health and Welfare, Narita, Japan.ORCID https://orcid.org/0000-0003-1004-8537
Makoto SamukawaDepartment of Neurology (SS, KI, DT), Keio University School of Medicine, Tokyo; Department of Neurology (AU, HH, MY), Graduate School of Medicine, Chiba University; Department of Neurology (YN, KU), Hanamaki General Hospital; Department of Neurology (MM), Tokyo Medical University; Department of Neurology (SK), Toho University Ohashi Medical Center, Tokyo; Division of Health Sciences (T. Kubota, MPT), Department of Clinical Laboratory and Biomedical Sciences, Osaka University Graduate School of Medicine; Department of Neurology (MS), Kindai University Faculty of Medicine, Sayama; Department of Neurology (NK), Neurology Chiba Clinic; Department of Neurology (T. Kimura), Hyogo Medical University, Nishinomiya; Department of Neurology (YS), National Hospital Organization Sendai Medical Center, Sendai; Department of Clinical Neuroscience and Therapeutics (TS), Hiroshima University; Department of Neurology (NM), National Hospital Organization Hokkaido Medical Center, Sapporo; and Department of Neurology (HM), International University of Health and Welfare, Narita, Japan.ORCID https://orcid.org/0000-0003-3464-0754
Kei IshizuchiDepartment of Neurology (SS, KI, DT), Keio University School of Medicine, Tokyo; Department of Neurology (AU, HH, MY), Graduate School of Medicine, Chiba University; Department of Neurology (YN, KU), Hanamaki General Hospital; Department of Neurology (MM), Tokyo Medical University; Department of Neurology (SK), Toho University Ohashi Medical Center, Tokyo; Division of Health Sciences (T. Kubota, MPT), Department of Clinical Laboratory and Biomedical Sciences, Osaka University Graduate School of Medicine; Department of Neurology (MS), Kindai University Faculty of Medicine, Sayama; Department of Neurology (NK), Neurology Chiba Clinic; Department of Neurology (T. Kimura), Hyogo Medical University, Nishinomiya; Department of Neurology (YS), National Hospital Organization Sendai Medical Center, Sendai; Department of Clinical Neuroscience and Therapeutics (TS), Hiroshima University; Department of Neurology (NM), National Hospital Organization Hokkaido Medical Center, Sapporo; and Department of Neurology (HM), International University of Health and Welfare, Narita, Japan.ORCID https://orcid.org/0000-0002-7901-5787
Daiki TokuyasuDepartment of Neurology (SS, KI, DT), Keio University School of Medicine, Tokyo; Department of Neurology (AU, HH, MY), Graduate School of Medicine, Chiba University; Department of Neurology (YN, KU), Hanamaki General Hospital; Department of Neurology (MM), Tokyo Medical University; Department of Neurology (SK), Toho University Ohashi Medical Center, Tokyo; Division of Health Sciences (T. Kubota, MPT), Department of Clinical Laboratory and Biomedical Sciences, Osaka University Graduate School of Medicine; Department of Neurology (MS), Kindai University Faculty of Medicine, Sayama; Department of Neurology (NK), Neurology Chiba Clinic; Department of Neurology (T. Kimura), Hyogo Medical University, Nishinomiya; Department of Neurology (YS), National Hospital Organization Sendai Medical Center, Sendai; Department of Clinical Neuroscience and Therapeutics (TS), Hiroshima University; Department of Neurology (NM), National Hospital Organization Hokkaido Medical Center, Sapporo; and Department of Neurology (HM), International University of Health and Welfare, Narita, Japan.ORCID https://orcid.org/0009-0007-6947-2910
Hideo HandaDepartment of Neurology (SS, KI, DT), Keio University School of Medicine, Tokyo; Department of Neurology (AU, HH, MY), Graduate School of Medicine, Chiba University; Department of Neurology (YN, KU), Hanamaki General Hospital; Department of Neurology (MM), Tokyo Medical University; Department of Neurology (SK), Toho University Ohashi Medical Center, Tokyo; Division of Health Sciences (T. Kubota, MPT), Department of Clinical Laboratory and Biomedical Sciences, Osaka University Graduate School of Medicine; Department of Neurology (MS), Kindai University Faculty of Medicine, Sayama; Department of Neurology (NK), Neurology Chiba Clinic; Department of Neurology (T. Kimura), Hyogo Medical University, Nishinomiya; Department of Neurology (YS), National Hospital Organization Sendai Medical Center, Sendai; Department of Clinical Neuroscience and Therapeutics (TS), Hiroshima University; Department of Neurology (NM), National Hospital Organization Hokkaido Medical Center, Sapporo; and Department of Neurology (HM), International University of Health and Welfare, Narita, Japan.ORCID https://orcid.org/0000-0002-0787-4486
Manato YasudaDepartment of Neurology (SS, KI, DT), Keio University School of Medicine, Tokyo; Department of Neurology (AU, HH, MY), Graduate School of Medicine, Chiba University; Department of Neurology (YN, KU), Hanamaki General Hospital; Department of Neurology (MM), Tokyo Medical University; Department of Neurology (SK), Toho University Ohashi Medical Center, Tokyo; Division of Health Sciences (T. Kubota, MPT), Department of Clinical Laboratory and Biomedical Sciences, Osaka University Graduate School of Medicine; Department of Neurology (MS), Kindai University Faculty of Medicine, Sayama; Department of Neurology (NK), Neurology Chiba Clinic; Department of Neurology (T. Kimura), Hyogo Medical University, Nishinomiya; Department of Neurology (YS), National Hospital Organization Sendai Medical Center, Sendai; Department of Clinical Neuroscience and Therapeutics (TS), Hiroshima University; Department of Neurology (NM), National Hospital Organization Hokkaido Medical Center, Sapporo; and Department of Neurology (HM), International University of Health and Welfare, Narita, Japan.ORCID https://orcid.org/0000-0002-2876-3857
Naoki KawaguchiDepartment of Neurology (SS, KI, DT), Keio University School of Medicine, Tokyo; Department of Neurology (AU, HH, MY), Graduate School of Medicine, Chiba University; Department of Neurology (YN, KU), Hanamaki General Hospital; Department of Neurology (MM), Tokyo Medical University; Department of Neurology (SK), Toho University Ohashi Medical Center, Tokyo; Division of Health Sciences (T. Kubota, MPT), Department of Clinical Laboratory and Biomedical Sciences, Osaka University Graduate School of Medicine; Department of Neurology (MS), Kindai University Faculty of Medicine, Sayama; Department of Neurology (NK), Neurology Chiba Clinic; Department of Neurology (T. Kimura), Hyogo Medical University, Nishinomiya; Department of Neurology (YS), National Hospital Organization Sendai Medical Center, Sendai; Department of Clinical Neuroscience and Therapeutics (TS), Hiroshima University; Department of Neurology (NM), National Hospital Organization Hokkaido Medical Center, Sapporo; and Department of Neurology (HM), International University of Health and Welfare, Narita, Japan.ORCID https://orcid.org/0009-0001-3872-857X
Takashi KimuraDepartment of Neurology (SS, KI, DT), Keio University School of Medicine, Tokyo; Department of Neurology (AU, HH, MY), Graduate School of Medicine, Chiba University; Department of Neurology (YN, KU), Hanamaki General Hospital; Department of Neurology (MM), Tokyo Medical University; Department of Neurology (SK), Toho University Ohashi Medical Center, Tokyo; Division of Health Sciences (T. Kubota, MPT), Department of Clinical Laboratory and Biomedical Sciences, Osaka University Graduate School of Medicine; Department of Neurology (MS), Kindai University Faculty of Medicine, Sayama; Department of Neurology (NK), Neurology Chiba Clinic; Department of Neurology (T. Kimura), Hyogo Medical University, Nishinomiya; Department of Neurology (YS), National Hospital Organization Sendai Medical Center, Sendai; Department of Clinical Neuroscience and Therapeutics (TS), Hiroshima University; Department of Neurology (NM), National Hospital Organization Hokkaido Medical Center, Sapporo; and Department of Neurology (HM), International University of Health and Welfare, Narita, Japan.ORCID https://orcid.org/0000-0002-0401-7227
Yasushi SuzukiDepartment of Neurology (SS, KI, DT), Keio University School of Medicine, Tokyo; Department of Neurology (AU, HH, MY), Graduate School of Medicine, Chiba University; Department of Neurology (YN, KU), Hanamaki General Hospital; Department of Neurology (MM), Tokyo Medical University; Department of Neurology (SK), Toho University Ohashi Medical Center, Tokyo; Division of Health Sciences (T. Kubota, MPT), Department of Clinical Laboratory and Biomedical Sciences, Osaka University Graduate School of Medicine; Department of Neurology (MS), Kindai University Faculty of Medicine, Sayama; Department of Neurology (NK), Neurology Chiba Clinic; Department of Neurology (T. Kimura), Hyogo Medical University, Nishinomiya; Department of Neurology (YS), National Hospital Organization Sendai Medical Center, Sendai; Department of Clinical Neuroscience and Therapeutics (TS), Hiroshima University; Department of Neurology (NM), National Hospital Organization Hokkaido Medical Center, Sapporo; and Department of Neurology (HM), International University of Health and Welfare, Narita, Japan.ORCID https://orcid.org/0000-0002-1952-9604
Takamichi SugimotoDepartment of Neurology (SS, KI, DT), Keio University School of Medicine, Tokyo; Department of Neurology (AU, HH, MY), Graduate School of Medicine, Chiba University; Department of Neurology (YN, KU), Hanamaki General Hospital; Department of Neurology (MM), Tokyo Medical University; Department of Neurology (SK), Toho University Ohashi Medical Center, Tokyo; Division of Health Sciences (T. Kubota, MPT), Department of Clinical Laboratory and Biomedical Sciences, Osaka University Graduate School of Medicine; Department of Neurology (MS), Kindai University Faculty of Medicine, Sayama; Department of Neurology (NK), Neurology Chiba Clinic; Department of Neurology (T. Kimura), Hyogo Medical University, Nishinomiya; Department of Neurology (YS), National Hospital Organization Sendai Medical Center, Sendai; Department of Clinical Neuroscience and Therapeutics (TS), Hiroshima University; Department of Neurology (NM), National Hospital Organization Hokkaido Medical Center, Sapporo; and Department of Neurology (HM), International University of Health and Welfare, Narita, Japan.ORCID https://orcid.org/0000-0003-3652-0772
Naoya MinamiDepartment of Neurology (SS, KI, DT), Keio University School of Medicine, Tokyo; Department of Neurology (AU, HH, MY), Graduate School of Medicine, Chiba University; Department of Neurology (YN, KU), Hanamaki General Hospital; Department of Neurology (MM), Tokyo Medical University; Department of Neurology (SK), Toho University Ohashi Medical Center, Tokyo; Division of Health Sciences (T. Kubota, MPT), Department of Clinical Laboratory and Biomedical Sciences, Osaka University Graduate School of Medicine; Department of Neurology (MS), Kindai University Faculty of Medicine, Sayama; Department of Neurology (NK), Neurology Chiba Clinic; Department of Neurology (T. Kimura), Hyogo Medical University, Nishinomiya; Department of Neurology (YS), National Hospital Organization Sendai Medical Center, Sendai; Department of Clinical Neuroscience and Therapeutics (TS), Hiroshima University; Department of Neurology (NM), National Hospital Organization Hokkaido Medical Center, Sapporo; and Department of Neurology (HM), International University of Health and Welfare, Narita, Japan.ORCID https://orcid.org/0009-0002-4971-9609
Masanori P TakahashiDepartment of Neurology (SS, KI, DT), Keio University School of Medicine, Tokyo; Department of Neurology (AU, HH, MY), Graduate School of Medicine, Chiba University; Department of Neurology (YN, KU), Hanamaki General Hospital; Department of Neurology (MM), Tokyo Medical University; Department of Neurology (SK), Toho University Ohashi Medical Center, Tokyo; Division of Health Sciences (T. Kubota, MPT), Department of Clinical Laboratory and Biomedical Sciences, Osaka University Graduate School of Medicine; Department of Neurology (MS), Kindai University Faculty of Medicine, Sayama; Department of Neurology (NK), Neurology Chiba Clinic; Department of Neurology (T. Kimura), Hyogo Medical University, Nishinomiya; Department of Neurology (YS), National Hospital Organization Sendai Medical Center, Sendai; Department of Clinical Neuroscience and Therapeutics (TS), Hiroshima University; Department of Neurology (NM), National Hospital Organization Hokkaido Medical Center, Sapporo; and Department of Neurology (HM), International University of Health and Welfare, Narita, Japan.ORCID https://orcid.org/0000-0002-5513-5012
Hiroyuki MuraiDepartment of Neurology (SS, KI, DT), Keio University School of Medicine, Tokyo; Department of Neurology (AU, HH, MY), Graduate School of Medicine, Chiba University; Department of Neurology (YN, KU), Hanamaki General Hospital; Department of Neurology (MM), Tokyo Medical University; Department of Neurology (SK), Toho University Ohashi Medical Center, Tokyo; Division of Health Sciences (T. Kubota, MPT), Department of Clinical Laboratory and Biomedical Sciences, Osaka University Graduate School of Medicine; Department of Neurology (MS), Kindai University Faculty of Medicine, Sayama; Department of Neurology (NK), Neurology Chiba Clinic; Department of Neurology (T. Kimura), Hyogo Medical University, Nishinomiya; Department of Neurology (YS), National Hospital Organization Sendai Medical Center, Sendai; Department of Clinical Neuroscience and Therapeutics (TS), Hiroshima University; Department of Neurology (NM), National Hospital Organization Hokkaido Medical Center, Sapporo; and Department of Neurology (HM), International University of Health and Welfare, Narita, Japan.ORCID https://orcid.org/0000-0003-1612-1440
Kimiaki UtsugisawaDepartment of Neurology (SS, KI, DT), Keio University School of Medicine, Tokyo; Department of Neurology (AU, HH, MY), Graduate School of Medicine, Chiba University; Department of Neurology (YN, KU), Hanamaki General Hospital; Department of Neurology (MM), Tokyo Medical University; Department of Neurology (SK), Toho University Ohashi Medical Center, Tokyo; Division of Health Sciences (T. Kubota, MPT), Department of Clinical Laboratory and Biomedical Sciences, Osaka University Graduate School of Medicine; Department of Neurology (MS), Kindai University Faculty of Medicine, Sayama; Department of Neurology (NK), Neurology Chiba Clinic; Department of Neurology (T. Kimura), Hyogo Medical University, Nishinomiya; Department of Neurology (YS), National Hospital Organization Sendai Medical Center, Sendai; Department of Clinical Neuroscience and Therapeutics (TS), Hiroshima University; Department of Neurology (NM), National Hospital Organization Hokkaido Medical Center, Sapporo; and Department of Neurology (HM), International University of Health and Welfare, Narita, Japan.ORCID https://orcid.org/0000-0001-9373-8167
Tokyo Medical University · JP
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Objectives: Efgartigimod, which has been well tolerated and efficacious in individuals with generalized myasthenia gravis (MG), is available in Japan not only for the treatment of anti-acetylcholine receptor-positive (AChR+) but also anti-muscle-specific receptor tyrosine kinase (MuSK+) and seronegative generalized MG. We report details of the use of efgartigimod for generalized MG in clinical practice in Japan. Methods: We included patients with generalized MG in the 2021 survey of Japan Myasthenia Gravis Registry (JAMG-R) study group who received an initial cycle of efgartigimod between May and September 2022. We defined "responders" as patients who achieved a score ≥2 points for MG activities of daily living (MG-ADL) in the first treatment cycle. The MG composite and the Revised scale of the 15-item Myasthenia Gravis-Quality of Life scale (MG-QOL15-r) were also evaluated. Results: Of 1,343 JAMG-R patients, 36 (2.7%) started efgartigimod (female 68%, age 53 years). Their serologic profiles were as follows: AChR+, n = 19 (53%); MuSK+, n = 6 (17%); and seronegative, n = 11 (31%). Twenty-six patients (72%) had refractory MG. There were 81 cycles of efgartigimod during the 26-week observation in 34 patients (average, 2.4 cycles). The mean interval between cycles was 5.9 weeks. A continuous 4-weekly infusion of efgartigimod was performed in 65 (80%) of 81 cycles. In the first cycle, the MG-ADL score of the 34 patients decreased significantly from 10.5 ± 4.3 to 6.9 ± 5.1 ( Discussion: Efgartigimod can be considered for the treatment of patients with generalized MG who do not achieve minimal manifestations, with a broad flexibility of patient selection and treatment schedules.
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