Evidence map›Paper›PMID 38544795›Full record

ReviewEClinicalMedicine2024

Consensus and controversy in the management of paediatric and adult patients with ovarian immature teratoma: the Malignant Germ Cell International Consortium perspective.

Farzana Pashankar, Matthew J Murray, Joanna Gell, Nicola MacDonald, Jonathan Shamash, Deborah F Billmire, Lindsay Klosterkemper, Thomas Olson, Michelle S Hirsch, Michelle Lockley and 2 more

Abstract readReview
In one paragraph

Review in EClinicalMedicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Imaging in gynecological disease (29): clinical and ultrasound features of primary ovarian immature teratoma.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Farzana PashankarDepartment of Pediatrics, Yale University School of Medicine, New Haven, CT, USA.
Matthew J MurrayDepartment of Pathology, Tennis Court Road, University of Cambridge, CB2 1QP, UK.
Joanna GellThe Center for Cancer and Blood Disorders, Connecticut Children's Medical Center, Hartford, CT, USA.
Nicola MacDonaldDepartment of Gynaecological Surgery, University College Hospital, University College London Hospital, NHS Foundation Trust, London, UK.
Jonathan ShamashDepartment of Medical Oncology, St Bartholomew's Hospital, London, W Smithfield, London, EC1A 7BE, UK.
Deborah F BillmireDepartment of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.
Lindsay KlosterkemperHarvard Medical School, Boston, MA, USA.
Thomas OlsonDepartment of Pediatrics, Aflac Cancer and Blood Disorders Center, Emory University School of Medicine, Atlanta, GA, USA.
Michelle S HirschDepartment of Pathology, Women's and Perinatal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Michelle LockleyDepartment of Medical Oncology, University College Hospital, University College London Hospital, NHS Foundation Trust, London, UK.
Sara StonehamDepartment of Paediatrics, University College Hospital, University College London Hospital, NHS Foundation Trust, London, UK.
A Lindsay FrazierHarvard Medical School, Boston, MA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ovarian immature teratoma (IT) is a rare neoplasm comprising ∼3% of ovarian cancers, occurring primarily in young females. Management presents several challenges, including those with elevated serum alpha-fetoprotein, potential confusion regarding pathology interpretation, and paucity of data to support decision-making. MaGIC (https://magicconsortium.com/) is an interdisciplinary international consortium of GCT experts from multiple subspecialties, with members receiving frequent queries regarding IT patient management. With evidence from published literature where available, we summarise consensus management of such patients. Given lack of published data, controversy in certain areas remains. The most obvious variance in practice is between paediatric and adult teams, despite very similar outcomes. Paediatric teams typically employ a surgery-only approach, whereas in adult practice, all patients, except those with stage IA, grade 1 (low-grade) tumours, still generally receive adjuvant chemotherapy. Given the rarity of ovarian IT and lack of published data, discussion with GCT experts and/or national advisory panels is recommended.

Indexed as

GradeImmature teratomaOvarianStage

Identifiers

PMID38544795
PMCPMC10965411

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.