Evidence map›Paper›PMID 38544780›Full record

ArticleFrontiers in aging neuroscience2024

Aging effects on the encoding/retrieval flip in associative memory: fMRI evidence from incidental contingency learning.

Else Schneider, Marko Rajkovic, Rudolf Krug, Marco P Caviezel, Carolin F Reichert, Oliver Bieri, André Schmidt, Stefan Borgwardt, Thomas Leyhe, Christoph Linnemann and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in aging neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 2 countries.

Else Schneider *Center of Affective, Stress and Sleep Disorders (ZASS), University Psychiatric Clinics (UPK), University of Basel, Basel, Switzerland.
Marko Rajkovic *Center of Old Age Psychiatry, University Psychiatric Clinics (UPK), University of Basel, Basel, Switzerland.
Rudolf KrugUniversity Psychiatric Clinics (UPK), University of Basel, Basel, Switzerland.
Marco P CaviezelCenter of Old Age Psychiatry, University Psychiatric Clinics (UPK), University of Basel, Basel, Switzerland.
Carolin F ReichertTransfaculty Research Platform Molecular and Cognitive Neuroscience, University of Basel, Basel, Switzerland.
Oliver BieriDivision of Radiological Physics, Department of Radiology and Nuclear Medicine Clinic, University Hospital Basel, University of Basel, Basel, Switzerland.
André SchmidtDepartment of Clinical Research (DKF), University Psychiatric Clinics (UPK), Translational Neurosciences, University of Basel, Basel, Switzerland.
Stefan BorgwardtDepartment of Clinical Research (DKF), University Psychiatric Clinics (UPK), Translational Neurosciences, University of Basel, Basel, Switzerland.
Thomas LeyheCenter of Old Age Psychiatry, University Psychiatric Clinics (UPK), University of Basel, Basel, Switzerland.
Christoph LinnemannCenter of Old Age Psychiatry, University Psychiatric Clinics (UPK), University of Basel, Basel, Switzerland.
Annette B BrühlCenter of Affective, Stress and Sleep Disorders (ZASS), University Psychiatric Clinics (UPK), University of Basel, Basel, Switzerland.
Undine E LangUniversity Psychiatric Clinics (UPK), University of Basel, Basel, Switzerland.
Tobias MelcherCenter of Old Age Psychiatry, University Psychiatric Clinics (UPK), University of Basel, Basel, Switzerland.
University of Basel · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Associative memory is arguably the most basic memory function and therein constitutes the foundation of all episodic and semantic memory processes. At the same time, the decline of associative memory represents a core feature of age-related cognitive decline in both, healthy and pathological (i.e., dementia-related) aging. The neural mechanisms underlying age-related impairments in associative memory are still not fully understood, especially regarding incidental (i.e., non-intentional) learning. Methods: We investigated the impact of age on the incidental learning and memory retrieval of face-name combinations in a total sample of 46 young ( Results: According to our hypothesis, the results showed a significant age-related decline in the retrieval performance in the old group. Additionally, at the neural level, we discovered an abolished E/R flip in the right anterior insula and a joint but reduced E/R flip activation magnitude in the posterior middle cingulate cortex in older subjects. Discussion: In conclusion, the present findings suggest that the impaired neural modulation of the E/R flip in the right aIC might be a sensitive marker in the early detection of neural aging.

Indexed as

age-effectanterior insular cortexassociative memoryencoding/retrieval flipincidental learningmiddle temporal gyrusposterior midline region

Identifiers

PMID38544780
PMCPMC10966385
OpenAlexW4392752719

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.