ArticleFrontiers in endocrinology2024
Phenotype of early-onset fetal growth restriction in sheep.
Article in Frontiers in endocrinology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 16 citations in OpenAlex.
- Hippocampal growth and function are reduced in the newborn following fetal growth restriction.Brain : a journal of neurology · 2026Article
- Understanding physiological adaptations of pregnancy to the chronic hypoxia of high altitude to inform obstetrical and neonatal care.Physiological reviews · 2026Review
- Insights from animal models: Dissecting the independent roles of oxygen and nutrients in the fetal origins of cardiovascular disease.The Journal of physiology · 2026Review
- Doppler Ultrasound Indices and Fetal Biometry as Prenatal Markers of SGA or Non-SGA Developmental Trajectories in Naturally Nutrient-Restricted Sheep Pregnancies from Patagonia.Animals : an open access journal from MDPI · 2026Article
- Sex-specific placental adaptations associated with fetal growth restriction: a review.Journal of animal science · 2026Review
- Antenatal melatonin for cardiovascular deficits in fetal growth restriction.The Journal of physiology · 2026Article
- In vivo and ex vivo cardiovascular haemodynamic responses of preterm growth-restricted lambs to perinatal asphyxia.Clinical science (London, England : 1979) · 2025Article
- Does Antenatal Lactoferrin Protect Hippocampal Development in Ovine Fetuses with Growth Restriction?Cells · 2025Article
- Compromised cardiopulmonary transition in fetal growth restricted and small for gestational age neonates.The Journal of physiology · 2025Review
- The human placenta and its role in reproductive outcomes revisited.Physiological reviews · 2025Review
- Fetal nutrient flux and oxidative metabolism during hypoxia: adaptive responses to defend fetal growth.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Article
- Fetal growth restriction adversely impacts trajectory of hippocampal neurodevelopment and function.Brain pathology (Zurich, Switzerland) · 2025Article
- The characteristics, influence factors, and regulatory strategies of growth retardation in ruminants: a review.Frontiers in veterinary science · 2025Review
- Dietary Supplementation with Rumen-Protected Arginine or N-Carbamylglutamate Enhances Fetal Liver Development in Nutrient-Restricted Pregnant Hu Ewes.Animals : an open access journal from MDPI · 2024Article
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Corrections and comments
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Authors and funding
16 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Fetal growth restriction (FGR) is a common pregnancy complication, caused by placental insufficiency, with serious adverse consequences for development Methods: FGR was induced via surgical placental insufficiency in fetal sheep (89 days gestation/0.6 gestation; n=135) and compared to age-matched controls over the last third of gestation and into neonatal life (n=153). Results: Body weight of FGR fetuses/lambs was significantly reduced compared to controls (p<0.0001) from 127 days of gestation (term is 148 days), with increased brain:body weight ratio (p<0.0001) indicative of brain sparing. All biometric measures of body size were reduced in the FGR group with the exception of biparietal (head) diameter. The trajectory of body growth in the last trimester of sheep pregnancy was significantly reduced in the FGR group compared to controls, and stillbirth rate increased with longer gestation. Discussion: This work provides a well characterised FGR animal model that mimics the known physiological adaptations in human pregnancy and can be used to determine the efficacy of potential interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.