Evidence map›Paper›PMID 38544669›Full record

ArticleInternational journal of reproductive biomedicine2024

Modulating the RFamide-related peptide-3/G protein-coupled receptor 147 signaling pathway with nourishing Yin-removing fire herbal mixture to alleviate precocious puberty in female rats: An experimental study.

Xiaoli Dai, Yuanyuan He, Suhuan Li, Yanyan Sun, Wen Sun, Zhanzhuang Tian, Ph D, Jian Yu, Ph D, Nurgul Ablakimova and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of reproductive biomedicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Xiaoli DaiTraditional Chinese Medicine Department, Children's Hospital of Fudan University, Shanghai, China.
Yuanyuan HeTraditional Chinese Medicine Department, Children's Hospital of Fudan University, Shanghai, China.
Suhuan LiYantaishan Hospital, Shangdong, China.
Yanyan SunTraditional Chinese Medicine Department, Children's Hospital of Fudan University, Shanghai, China.
Wen SunTraditional Chinese Medicine Department, Children's Hospital of Fudan University, Shanghai, China.
Zhanzhuang TianDepartment of Integrative Medicine and Neurobiology, Fudan University, Shanghai, China.
Ph DTraditional Chinese Medicine Department, Children's Hospital of Fudan University, Shanghai, China.
Jian YuTraditional Chinese Medicine Department, Children's Hospital of Fudan University, Shanghai, China.
Ph DTraditional Chinese Medicine Department, Children's Hospital of Fudan University, Shanghai, China.
Nurgul AblakimovaDepartment of Pharmacology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan.
Yonghong WangTraditional Chinese Medicine Department, Children's Hospital of Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0002-4756-2081
West Kazakhstan Marat Ospanov State Medical University · KZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Precocious puberty (PP) involves early activation of the hypothalamic gonadotropin-releasing hormone (GnRH) generator. The RFamide-related peptide/G protein-coupled receptor 147 ( Objective: This study aimed to assess the impact of the NYRF herbal mixture on the Materials and Methods: In a controlled experiment, 24 female Sprague-Dawley rats (11.20 Results: In the model group, hypothalamic GnRH and kisspeptin levels increased, while RFRP3 and GPR147 levels decreased, luteinizing hormone levels elevated, reproductive organ coefficients increased, and the vagina opened earlier compared to the normal group. Conversely, the NYRF group exhibited lower GnRH and kisspeptin levels but higher RFRP3 levels in the hypothalamus. Serum luteinizing hormone levels were reduced, reproductive organ coefficients were reduced, and the vaginal opening was delayed compared to the model and normal saline groups. Conclusion: The NYRF herbal mixture delayed sexual development in rats with PP by hypothalamic upregulating RFRP3 and downregulating GnRH and kisspeptin.

Indexed as

G protein-coupled receptor 147HypothalamusNourishing Yin-removing firePrecocious.PubertyRFamide-related peptide-3

Identifiers

PMID38544669
PMCPMC10963877
OpenAlexW4392158553

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.