Evidence map›Paper›PMID 38544665›Full record

ArticleInternational journal of reproductive biomedicine2024

Aspirin administration from early pregnancy versus initiation after 11 weeks of gestation for prevention of pre-eclampsia in high-risk pregnant women: Study protocol for randomized controlled trial.

Sedigheh Hantoushzadeh, Arezoo Behzadian, Mohammad Mehdi Hasheminejad, Faezeh Hasheminejad, Alireza Helal Birjandi, Mojtaba Akbari, Marjan Ghaemi

Abstract read
In one paragraph

Article in International journal of reproductive biomedicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Aspirin before the 11International journal of reproductive biomedicine · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sedigheh HantoushzadehVali-E-Asr Reproductive Health Research Center, Family Health Research Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
Arezoo BehzadianDepartment of Perinatology, Vali-E-Asr Hospital, Imam Khomeini Hospital Complex, Tehran, Iran.ORCID https://orcid.org/0009-0005-0301-5309
Mohammad Mehdi HasheminejadIran University of Medical Sciences, Tehran, Iran.
Faezeh HasheminejadAsklepios Psychiatry Lower Saxony GmbH, Asklepios Specialist Clinic, Gottingen, Germany.
Alireza Helal BirjandiHannover Medical School, Clinic for Urology, Hannover, Germany.
Mojtaba AkbariIsfahan Endocrine and Metabolism Research Center, Isfahan University of Medicine Sciences, Isfahan, Iran.
Marjan GhaemiVali-E-Asr Hospital, Imam Khomeini Hospital Complex, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Pre-eclampsia (PE) is a multiorgan disorder that affects 2-5% of all pregnant women. Present recommendations for when to start aspirin in high-risk women are after 11 wk of gestation. Objective: We present a protocol to investigate the effectiveness of aspirin use from early pregnancy, which is a randomized controlled trial to assess whether prescribed low-dose aspirin from early pregnancy reduces the prevalence of early and late-onset PE. Additionally, to compare the effectiveness of aspirin administration before and after 11 wk in reducing the occurrence of PE? Materials and Methods: All pregnancies at risk of PE, according to demographic and midwifery history, who are referred to the Maternal-Fetal Clinic of Tehran University hospital, Tehran, Iran were invited to take part in the trial. The outcomes of pregnancy and newborns will be gathered and analyzed. The first registration for the pilot study was in January 2023, and the participants were recognized as high-risk for PE. In addition, enrollment in the main study will begin as of October 2023.

Indexed as

AspirinColor doppler ultrasonographyFirst trimesterPre-eclampsiaPregnancyPregnancy-associated plasma protein-A.

Identifiers

PMID38544665
PMCPMC10963873

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.