Evidence map›Paper›PMID 38544431›Full record

ArticleJournal of child neurology2024

Brain Volumes in Opsoclonus-Myoclonus Ataxia Syndrome: A Longitudinal Study.

Montaha Almudhry, Matthias W Wagner, Giulia Longoni, Carmen Yea, Logi Vidarsson, Birgit Ertl-Wagner, E Ann Yeh

Abstract read
In one paragraph

Article in Journal of child neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Observational
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Montaha AlmudhryProgram in Neurosciences and Mental Health, SickKids Research Institute, The Hospital for Sick Children, Canada.
Matthias W WagnerDivision of Neuroradiology, Department of Diagnostic and Interventional Radiology, The Hospital for Sick Children, Toronto, Ontario, Canada.
Giulia LongoniProgram in Neurosciences and Mental Health, SickKids Research Institute, The Hospital for Sick Children, Canada.
Carmen YeaProgram in Neurosciences and Mental Health, SickKids Research Institute, The Hospital for Sick Children, Canada.
Logi VidarssonDivision of Neuroradiology, Department of Diagnostic and Interventional Radiology, The Hospital for Sick Children, Toronto, Ontario, Canada.
Birgit Ertl-WagnerProgram in Neurosciences and Mental Health, SickKids Research Institute, The Hospital for Sick Children, Canada.
E Ann YehProgram in Neurosciences and Mental Health, SickKids Research Institute, The Hospital for Sick Children, Canada.ORCID 0000-0002-5393-7417

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionLittle is known about the longitudinal trajectory of brain growth in children with opsoclonus-myoclonus ataxia syndrome. We performed a longitudinal evaluation of brain volumes in pediatric opsoclonus-myoclonus ataxia syndrome patients compared with age- and sex-matched healthy children. PATIENTS AND

methodsThis longitudinal case-control study included brain magnetic resonance imaging (MRI) scans from consecutive pediatric opsoclonus-myoclonus ataxia syndrome patients (2009-2020) and age- and sex-matched healthy control children. FreeSurfer analysis provided automatic volumetry of the brain. Paired

resultsA total of 14 opsoclonus-myoclonus ataxia syndrome patients (12 female) and 474 healthy control children (406 female) were included. Curvature of the growth trajectories of the cerebral white and gray matter, cerebellar white and gray matter, and brainstem differed significantly between opsoclonus-myoclonus ataxia syndrome patients and healthy control children (cerebral white matter, DISCUSSION/

conclusionWe found abnormal brain maturation in the supratentorial brain, brainstem, and cerebellum in children with opsoclonus-myoclonus ataxia syndrome.

Indexed as

BrainMagnetic Resonance ImagingOpsoclonus-Myoclonus SyndromeAdolescentCase-Control StudiesChildChild, PreschoolFemaleHumansLongitudinal StudiesMaleOrgan Sizebrain volumesOMASpediatric

Identifiers

PMID38544431
PMCPMC11102640

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.