Evidence map›Paper›PMID 38544400›Full record

ArticleJournal of veterinary internal medicine

Congenital spongiform leukodystrophy in 2 female littermate German shepherd puppies.

Ricardo De Miguel, Devon Wallis Hague, Jennifer L Johnson, Amber M Zilinger, Anna Kukekova, Stephane Lezmi

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of veterinary internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 3 countries.

Ricardo De MiguelAnaPath Services GmbH, Liestal, Switzerland.
Devon Wallis HagueDepartment of Veterinary Clinical Medicine, University of Illinois, Urbana, Illinois, USA.
Jennifer L JohnsonDepartment of Animal Sciences, College of Agricultural, Consumer and Environmental Sciences, University of Illinois at Urbana-Champaign, Champaign, Illinois, USA.
Amber M ZilingerDepartment of Animal Sciences, College of Agricultural, Consumer and Environmental Sciences, University of Illinois at Urbana-Champaign, Champaign, Illinois, USA.
Anna KukekovaDepartment of Animal Sciences, College of Agricultural, Consumer and Environmental Sciences, University of Illinois at Urbana-Champaign, Champaign, Illinois, USA.
Stephane LezmiDepartment of Pathobiology, University of Illinois at Urbana-Champaign, Champaign, Illinois, USA.ORCID https://orcid.org/0000-0002-3412-4058
University of Illinois Urbana-Champaign · USPsychiatry Baselland · CH

Funding

Molecular Mechanisms of Social BehaviorR35GM144276 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI ANNA KUKEKOVA · 2022 to 2026
$2.1M
Molecular Mechanisms of Social BehaviorR01GM120782 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI KUKEKOVA, ANNA · 2016 to 2019
$1.6M
NIGMS NIH HHS R01 GM120782NIGMS NIH HHS R35 GM144276
6 · The paper itself

Abstract

Two 9-week-old female littermate German Shepherd puppies showed severe high-frequency low-amplitude trembling that worsened with movement. The white matter (WM) of the central nervous system (CNS) showed bilateral diffuse severe spongiosis in the cerebellum, brainstem, spinal cord, and the neuropil of the oculomotor and red nuclei. The cortical corona radiata was less severely affected. Rare necrotic or apoptotic glia-like cells also were identified in the WM. Luxol fast blue staining disclosed severe diffuse myelin loss in the entire CNS; peripheral nerves were spared. Glial fibrillary acidic protein immunohistochemistry showed diffuse astrogliosis and astrocytosis in the WM. Genetic analyses of the littermates excluded the aspartoacylase (ASPA) gene as a candidate for this condition in dogs. In conclusion, this description of a rare congenital spongiform leukodystrophy in the German Shepherd breed, closely resembling to Canavan disease in humans, is likely caused by a genetic alteration unrelated to the ASPA gene.

Indexed as

Dog DiseasesAnimalsBrainDogsFemaleASPA geneaspartoacylaseCanavan diseasemyelin

Identifiers

PMID38544400
PMCPMC11099797
OpenAlexW4393272452

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.