Evidence map›Paper›PMID 38543926›Full record

ArticleVaccines2024

Vaccination with Adenovirus Type 5 Vector-Based COVID-19 Vaccine as the Primary Series in Adults: A Randomized, Double-Blind, Placebo-Controlled Phase 1/2 Clinical Trial.

Yawen Zhu, Rong Tang, Xiaolong Li, Xiaoqin Chen, Xue Wang, Ying Wang, Ruijie Wang, Fengcai Zhu, Jingxin Li

Abstract read
In one paragraph

Article in Vaccines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Developing the next-generation of adenoviral vector vaccines.Human vaccines & immunotherapeutics · 2025
    Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yawen ZhuSchool of Public Health, National Vaccine Innovation Platform, Nanjing Medical University, Nanjing 211166, China.
Rong TangJiangsu Provincial Medical Innovation Center, National Health Commission Key Laboratory of Enteric Pathogenic Microbiology, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China.
Xiaolong LiCanSino Biologics Inc., Tianjin 300457, China.
Xiaoqin ChenDonghai Center for Disease Control and Prevention, Lianyungang 222300, China.
Xue WangCanSino Biologics Inc., Tianjin 300457, China.
Ying WangCanSino Biologics Inc., Tianjin 300457, China.
Ruijie WangCanSino Biologics Inc., Tianjin 300457, China.
Fengcai ZhuSchool of Public Health, National Vaccine Innovation Platform, Nanjing Medical University, Nanjing 211166, China.
Jingxin LiSchool of Public Health, National Vaccine Innovation Platform, Nanjing Medical University, Nanjing 211166, China.

Funding

Jiangsu Provincial Key Project of Science and Technology Plan BE2021738 and BE2023601Jiangsu Provincial Science Fund for Distinguished Young Scholars BK20220064Major Research Plan of the National Natural Science Foundation of China 92269205National Natural Science Foundation of China 82341031, 82173584, and 82222062
6 · The paper itself

Abstract

This randomized, double-blind, placebo-controlled phase 1/2 trial aimed at evaluating the safety and immunogenicity of Ad5-nCoV via aerosolized or intramuscular or intramuscular-aerosolized routes in SARS-CoV-2-negative adults aged over 18 years. In the phase 1 trial, participants were sequentially enrolled into one of five regimen cohorts: Low-Dose (two doses of aerosolized Ad5-nCoV with 0.5 × 10

Indexed as

aerosolized Ad5-nCoVCOVID-19 vaccineimmunogenicityprimary series vaccinationsafety

Identifiers

PMID38543926
PMCPMC10975308

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.