Evidence map›Paper›PMID 38543923›Full record

ArticleVaccines2024

Pregnancy Outcomes among Pregnant Persons after COVID-19 Vaccination: Assessing Vaccine Safety in Retrospective Cohort Analysis of U.S. National COVID Cohort Collaborative (N3C).

Emily A G Faherty, Kenneth J Wilkins, Sara Jones, Anup Challa, Qiuyuan Qin, Lauren E Chan, Courtney Olson-Chen, Jessica L Tarleton, Michael N Liebman, Federico Mariona and 3 more

Open access · goldAbstract read
In one paragraph

Article in Vaccines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. The Effectiveness and Influence of COVID-19 Vaccination on Perinatal Individuals and Their Newborns: An Updated Meta-Analysis.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2025
    Review
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 9 institutions in 1 country.

Emily A G FahertyDivision of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN 55455, USA.ORCID 0000-0003-1636-7061
Kenneth J WilkinsBiostatistics Program, Office of the Director, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0003-0531-7165
Sara JonesOffice of Data Science and Emerging Technologies, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20892, USA.
Anup ChallaVanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN 37203, USA.
Qiuyuan QinDepartment of Public Health Sciences, University of Rochester Medical Center, Rochester, NY 14642, USA.
Lauren E ChanDepartment of Pediatrics, University of Chicago, Chicago, IL 60637, USA.
Courtney Olson-ChenDepartment of Obstetrics and Gynecology, University of Rochester Medical Center, Rochester, NY 14620, USA.
Jessica L TarletonDepartment of Obstetrics and Gynecology, Medical University of South Carolina, Charleston, SC 29425, USA.
Michael N LiebmanIPQ Analytics, LLC, Kennett Square, PA 19348, USA.ORCID 0000-0002-8626-8432
Federico MarionaBeaumont Hospital, Dearborn, MI 48124, USA.
Elaine L HillDepartment of Public Health Sciences, University of Rochester Medical Center, Rochester, NY 14642, USA.ORCID 0000-0003-2494-317X
Rena C PatelDepartments of Medicine and Global Health, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0001-9893-5856
The N C Consortium
University of Rochester Medical Center · USNational Institutes of Health · USEP Analytics (United States) · USMedical University of South Carolina · USUniversity of Chicago · USUniversity of Minnesota · USUniversity of Washington · USVanderbilt University Medical Center · USWayne State University · US

Funding

Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE)UL1TR002378 · NCATS · EMORY UNIVERSITY · PI Andres J Garcia, Elizabeth O. Ofili · 2017 to 2026
$92.1M
VISUAL INDICES OF NEUROTOXICITYP30ES001247 · NIEHS · UNIVERSITY OF ROCHESTER · PI Martha Susiarjo · 1985 to 2026
$42.8M
The tale of two pandemics: Understanding racial and ethnic disparities from the collision of HIV and COVID-19 in the U.S.R01MH131542 · NIMH · UNIVERSITY OF WASHINGTON · PI Rena Chiman Patel · 2022 to 2026
$3.1M
NCATS NIH HHS UL1 TR002378NIEHS NIH HHS P30 ES001247NIMH NIH HHS R01 MH131542
6 · The paper itself

Abstract

COVID-19 vaccines have been shown to be effective in preventing severe illness, including among pregnant persons. The vaccines appear to be safe in pregnancy, supporting a continuously favorable overall risk/benefit profile, though supportive data for the U.S. over different periods of variant predominance are lacking. We sought to analyze the association of adverse pregnancy outcomes with COVID-19 vaccinations in the pre-Delta, Delta, and Omicron SARS-CoV-2 variants' dominant periods (constituting 50% or more of each pregnancy) for pregnant persons in a large, nationally sampled electronic health record repository in the U.S. Our overall analysis included 311,057 pregnant persons from December 2020 to October 2023 at a time when there were approximately 3.6 million births per year. We compared rates of preterm births and stillbirths among pregnant persons who were vaccinated before or during pregnancy to persons vaccinated after pregnancy or those who were not vaccinated. We performed a multivariable Poisson regression with generalized estimated equations to address data site heterogeneity for preterm births and unadjusted exact models for stillbirths, stratified by the dominant variant period. We found lower rates of preterm birth in the majority of modeled periods (adjusted incidence rate ratio [aIRR] range: 0.42 to 0.85;

Indexed as

COVID-19 vaccinationpregnancypreterm birthreal-world datasafetystillbirthU.S.

Identifiers

PMID38543923
PMCPMC10975285
OpenAlexW4392652752

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.