Evidence map›Paper›PMID 38543918›Full record

ArticleVaccines2024

Anti-SARS-CoV-2 IgG Seroprevalence in Tyrol, Austria, among 28,768 Blood Donors between May 2022 and March 2023.

Anita Siller, Lisa Seekircher, Manfred Astl, Lena Tschiderer, Gregor A Wachter, Julia Penz, Bernhard Pfeifer, Andreas Huber, Manfred Gaber, Harald Schennach and 1 more

Open access · goldAbstract read
In one paragraph

Article in Vaccines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Anita SillerCentral Institute for Blood Transfusion and Immunology, University Hospital Innsbruck, Tirol Kliniken GmbH, 6020 Innsbruck, Austria.ORCID 0009-0003-7860-7144
Lisa SeekircherInstitute of Health Economics, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0003-0260-3262
Manfred AstlCentral Institute for Blood Transfusion and Immunology, University Hospital Innsbruck, Tirol Kliniken GmbH, 6020 Innsbruck, Austria.
Lena TschidererInstitute of Health Economics, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0001-7988-853X
Gregor A WachterCentral Institute for Blood Transfusion and Immunology, University Hospital Innsbruck, Tirol Kliniken GmbH, 6020 Innsbruck, Austria.
Julia PenzCentral Institute for Blood Transfusion and Immunology, University Hospital Innsbruck, Tirol Kliniken GmbH, 6020 Innsbruck, Austria.
Bernhard PfeiferTyrolean Federal Institute for Integrated Care, Tirol Kliniken GmbH, 6020 Innsbruck, Austria.
Andreas HuberTyrolean Federal Institute for Integrated Care, Tirol Kliniken GmbH, 6020 Innsbruck, Austria.
Manfred GaberBlood Donor Service Tyrol of the Austrian Red Cross, 6063 Rum, Austria.
Harald SchennachCentral Institute for Blood Transfusion and Immunology, University Hospital Innsbruck, Tirol Kliniken GmbH, 6020 Innsbruck, Austria.
Peter WilleitInstitute of Health Economics, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0002-1866-7159
Tirol Kliniken · ATInnsbruck Medical University · ATAustrian Red Cross · ATUMIT - Private Universität für Gesundheitswissenschaften, Medizinische Informatik und Technik · AT

Funding

Federal State of Tyrol LSD-A-6/2/107-2021Federal State of Tyrol LSD-A-6/2/131-2021Federal State of Tyrol LSD-A-6/2/145-2022Federal State of Tyrol ZI. FIN-1/103/1189-2021Tirol Kliniken GmbH N/A
6 · The paper itself

Abstract

backgroundTo provide updated estimates on SARS-CoV-2 antibody seroprevalence and average antibody titres for Central Europe.

methodsIn repeat cross-sectional investigations (1 May 2022 to 9 March 2023) involving 28,768 blood donors in the Federal State of Tyrol, Austria (participation rate: 87.0%), we measured Spike receptor-binding domain (RBD) and Nucleocapsid IgG antibodies (37,065 and 12,645 samples), and estimated monthly seroprevalences and geometric mean titres.

resultsMedian age of participants was 45.4 years (range 18-70); 43.2% were female. Spike RBD IgG antibody seroprevalence was 96.3% (95% CI: 95.6-96.9%) in May 2022, 97.4% (96.7-98.0%) in December 2022, and 97.9% (96.4-98.8%) in March 2023. Among seropositive participants, geometric mean titres increased from 1400 BAU/mL (95% CI: 1333-1471) in May 2022 to 1821 BAU/mL (1717-1932) in December 2022, and dropped to 1559 BAU/mL (1405-1729) by March 2023. Furthermore, titres differed markedly by vaccination status and history of infection, with being the highest in participants with booster vaccination and prior infection. In autumn 2022, Nucleocapsid IgG antibody seroprevalence ranged from 36.5% (35.0-38.1) in September to 39.2% (37.2-41.2) in December 2022.

conclusionSeroprevalence of SARS-CoV-2 antibodies in blood donors from Tyrol, Austria, was remarkably stable from May 2022 to March 2023. In contrast, average Spike RBD IgG antibody titres peaked in December 2022.

Indexed as

blood donorsCOVID-19Nucleocapsid IgG antibodiesSARS-CoV-2 IgG antibodiesseroprevalenceSpike IgG antibodies

Identifiers

PMID38543918
PMCPMC10976183
OpenAlexW4392595938

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.