Evidence map›Paper›PMID 38543868›Full record

ArticleVaccines2024

New Vaccine Platforms-Novel Dimensions of Economic and Societal Value and Their Measurement.

Philip O Buck, Dumingu Aparna Gomes, Ekkehard Beck, Noam Kirson, Matthew Mattera, Stuart Carroll, Bernhard Ultsch, Kavisha Jayasundara, Mathieu Uhart, Louis P Garrison

Abstract read
In one paragraph

Article in Vaccines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Philip O BuckModerna Inc., Cambridge, MA 02139, USA.
Dumingu Aparna GomesAnalysis Group, Inc., Menlo Park, CA 94025, USA.ORCID 0000-0003-4498-8201
Ekkehard BeckModerna Inc., Cambridge, MA 02139, USA.
Noam KirsonAnalysis Group, Inc., Boston, MA 02199, USA.ORCID 0000-0001-5200-6883
Matthew MatteraAnalysis Group, Inc., New York City, NY 10036, USA.ORCID 0009-0001-4418-7263
Stuart CarrollModerna Inc., London SW1E 6DE, UK.
Bernhard UltschModerna Germany GmbH, 81671 München, Germany.
Kavisha JayasundaraModerna Inc., Toronto, ON M5V 0C3, Canada.
Mathieu UhartModerna Inc., 75007 Paris, France.
Louis P GarrisonSchool of Pharmacy, University of Washington, Seattle, WA 98195, USA.

Funding

Moderna Therapeutics (United States) #NA
6 · The paper itself

Abstract

The COVID-19 pandemic's dramatic impact has been a vivid reminder that vaccines-especially in the context of infectious respiratory viruses-provide enormous societal value, well beyond the healthcare system perspective which anchors most Health Technology Assessment (HTA) and National Immunization Technical Advisory Group (NITAG) evaluation frameworks. Furthermore, the development of modified ribonucleic acid-based (mRNA-based) and nanoparticle vaccine technologies has brought into focus several new value drivers previously absent from the discourse on vaccines as public health interventions such as increased vaccine adaptation capabilities, the improved ability to develop combination vaccines, and more efficient vaccine manufacturing and production processes. We review these novel value dimensions and discuss how they might be measured and incorporated within existing value frameworks using existing methods. To realize the full potential of next-generation vaccine platforms and ensure their widespread availability across populations and health systems, it is important that value frameworks utilized by HTAs and NITAGs properly reflect the full range of benefits for population health and well-being and cost efficiencies that these new vaccines platforms provide.

Indexed as

health technology assessmentnext-generation vaccine platformsNITAGsvaccinesvalue frameworkvalue measurement

Identifiers

PMID38543868
PMCPMC10974797

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.