Evidence map›Paper›PMID 38543777›Full record

ArticleViruses2024

Occult HBV Infection in Patients Infected by HIV or HCV: Comparison between HBV-DNA and Two Assays for HBsAg.

Silvia Meschi, Klizia Mizzoni, Bruno Daniele Leoni, Claudio Galli, Anna Rosa Garbuglia, Stefano Belladonna, Enrico Girardi, Fabrizio Maggi, The Hbsagn Study Group

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Silvia MeschiLaboratory of Virology, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149 Rome, Italy.ORCID 0000-0003-0924-993X
Klizia MizzoniLaboratory of Virology, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149 Rome, Italy.
Bruno Daniele LeoniValidation & Verification, Core Laboratory, Abbott, 00144 Rome, Italy.ORCID 0000-0003-1428-8837
Claudio GalliIndependent Researcher, 00139 Rome, Italy.ORCID 0000-0002-0804-0387
Anna Rosa GarbugliaLaboratory of Virology, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149 Rome, Italy.ORCID 0000-0002-2687-8642
Stefano BelladonnaAbbott Molecular, Abbott, 00144 Rome, Italy.
Enrico GirardiScientific Direction, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149 Rome, Italy.ORCID 0000-0001-8182-5896
Fabrizio MaggiLaboratory of Virology, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149 Rome, Italy.ORCID 0000-0001-7489-5271
The Hbsagn Study Group
Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani · IT

Funding

Abbott s.r.l. protocol n. 317, 2022Ministero della Salute, Italy Ricerca Corrente Linea 3
6 · The paper itself

Abstract

We investigated the frequency and serological correlates of occult hepatitis B virus infection (OBI) and the potential impact of a highly sensitive assay for HBsAg in subjects infected by human immunodeficiency virus (HIV) or hepatitis C virus (HCV), who are also at risk for hepatitis B virus (HBV) infection, often in an occult form. Samples from 499 patients with HIV, all HBsAg negative and anti-HBc positive, and 137 patients with HCV were tested for HBV-DNA, anti-HBc, anti-HBs, and HBsAg by a conventional and highly sensitive assay. HBV biomarkers were detected in 71.5% of HCV-RNA-positive, with a higher prevalence of cases positive only for anti-HBc in patients with HCV than in those with HIV. HBV-DNA was detectable in 0.6% of HIV-positive and 7.3% of HCV-RNA-positive patients. Among patients with HCV, four were positive for HBsAg and negative for HBV-DNA, bringing the rate of HBV-active infection in this group to 10.2%. Active HBV infection was not related to gender or specific patterns of HBV biomarkers but was higher in HCV patients coinfected by HIV compared to those infected only by HCV. Monitoring patients at high risk for HBV infection and reactivation may require testing for both HBV-DNA and HBsAg.

Indexed as

Hepatitis BHepatitis B, ChronicHepatitis CHIV InfectionsBiomarkersDNA, ViralHepacivirusHepatitis B AntibodiesHepatitis B Surface AntigensHepatitis B virusHIVHumansPrevalenceRNABiomarkersDNA, ViralHepatitis B AntibodiesHepatitis B Surface AntigensRNAanti-HBcHBsAgHBV-DNAHCVHIVoccult hepatitis B (OBI)

Identifiers

PMID38543777
PMCPMC10974054
OpenAlexW4392561890

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.