Evidence map›Paper›PMID 38543746›Full record

ArticleViruses2024

Transcriptomic Responses to Koi Herpesvirus in Isolated Blood Leukocytes from Infected Common Carp.

Irene Cano, Ellen Blaker, David Hartnell, Audrey Farbos, Karen A Moore, Adele Cobb, Eduarda M Santos, Ronny van Aerle

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Irene CanoInternational Centre of Excellence for Aquatic Animal Health, Cefas Laboratory, Dorset DT4 8UB, UK.ORCID 0000-0001-8468-3707
Ellen BlakerInternational Centre of Excellence for Aquatic Animal Health, Cefas Laboratory, Dorset DT4 8UB, UK.
David HartnellInternational Centre of Excellence for Aquatic Animal Health, Cefas Laboratory, Dorset DT4 8UB, UK.
Audrey FarbosBiosciences, Faculty of Life and Health Sciences, University of Exeter, Exeter EX2 4TH, UK.
Karen A MooreBiosciences, Faculty of Life and Health Sciences, University of Exeter, Exeter EX2 4TH, UK.
Adele CobbInternational Centre of Excellence for Aquatic Animal Health, Cefas Laboratory, Dorset DT4 8UB, UK.
Eduarda M SantosCentre for Sustainable Aquaculture Futures, University of Exeter, Exeter EX2 4TH, UK.
Ronny van AerleInternational Centre of Excellence for Aquatic Animal Health, Cefas Laboratory, Dorset DT4 8UB, UK.ORCID 0000-0002-2605-6518
Centre for Environment, Fisheries and Aquaculture Science · GBUniversity of Exeter · GB

Funding

Biotechnology and Biological Sciences Research Council BB/S004297/1Biotechnology and Biological Sciences Research Council BB/S004300/1Wellcome TrustWellcome Trust 218247/Z/19/Z
6 · The paper itself

Abstract

Koi herpesvirus (KHV, CyHV-3) causes severe economic losses in carp farms. Its eradication is challenging due to the establishment of latency in blood leukocytes and other tissues. To understand the molecular mechanisms leading to KHV infection in leukocytes, common carp were bath-exposed to KHV at 17 °C. After confirming the presence of viral transcripts in blood leukocytes at ten days post infection, RNA-Seq was performed on peripheral blood leukocytes on the Illumina NovaSeq. KHV infection triggered a robust immune response mediated by pattern recognition receptors, mainly toll-like receptors (

Indexed as

CarpsFish DiseasesHerpesviridaeHerpesviridae InfectionsAnimalsGene Expression ProfilingLeukocytesVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Ablood leukocytecommon carpimmunosuppressioninflammationkoi herpesvirus (KHV, CyHV-3)M2 macrophagepattern recognition receptorstoll-like receptorstranscriptomics

Identifiers

PMID38543746
PMCPMC10974277
OpenAlexW4392286974

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.