Evidence map›Paper›PMID 38543742›Full record

ArticleViruses2024

Deletion of the EP402R Gene from the Genome of African Swine Fever Vaccine Strain ASFV-G-∆I177L Provides the Potential Capability of Differentiating between Infected and Vaccinated Animals.

Manuel V Borca, Elizabeth Ramirez-Medina, Nallely Espinoza, Ayushi Rai, Edward Spinard, Lauro Velazquez-Salinas, Alyssa Valladares, Ediane Silva, Leeanna Burton, Amanda Meyers and 4 more

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

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  11. Towards Safe African Swine Fever Vaccines: TheAnimals : an open access journal from MDPI · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Manuel V BorcaForeign Animal Disease Research Unit, Plum Island Animal Disease Center, U.S. Department of Agriculture, Agricultural Research Service, Orient, NY 11957, USA.
Elizabeth Ramirez-MedinaForeign Animal Disease Research Unit, Plum Island Animal Disease Center, U.S. Department of Agriculture, Agricultural Research Service, Orient, NY 11957, USA.
Nallely EspinozaForeign Animal Disease Research Unit, Plum Island Animal Disease Center, U.S. Department of Agriculture, Agricultural Research Service, Orient, NY 11957, USA.
Ayushi RaiForeign Animal Disease Research Unit, Plum Island Animal Disease Center, U.S. Department of Agriculture, Agricultural Research Service, Orient, NY 11957, USA.
Edward SpinardForeign Animal Disease Research Unit, Plum Island Animal Disease Center, U.S. Department of Agriculture, Agricultural Research Service, Orient, NY 11957, USA.ORCID 0000-0001-7268-6580
Lauro Velazquez-SalinasForeign Animal Disease Research Unit, Plum Island Animal Disease Center, U.S. Department of Agriculture, Agricultural Research Service, Orient, NY 11957, USA.
Alyssa ValladaresForeign Animal Disease Research Unit, Plum Island Animal Disease Center, U.S. Department of Agriculture, Agricultural Research Service, Orient, NY 11957, USA.
Ediane SilvaForeign Animal Disease Research Unit, U.S. Department of Agriculture, Agricultural Research Service, National Bio and Agro-Defense Facility, Manhattan, KS 66502, USA.ORCID 0000-0001-5155-1361
Leeanna BurtonForeign Animal Disease Research Unit, U.S. Department of Agriculture, Agricultural Research Service, National Bio and Agro-Defense Facility, Manhattan, KS 66502, USA.ORCID 0009-0003-0943-0461
Amanda MeyersForeign Animal Disease Research Unit, Plum Island Animal Disease Center, U.S. Department of Agriculture, Agricultural Research Service, Orient, NY 11957, USA.
Jason ClarkForeign Animal Disease Research Unit, U.S. Department of Agriculture, Agricultural Research Service, National Bio and Agro-Defense Facility, Manhattan, KS 66502, USA.
Ping WuPlum Island Animal Disease Center, U.S. Department of Agriculture, Animal and Plant Health Inspection Service, Orient, NY 11957, USA.ORCID 0000-0003-3475-6335
Cyril G GayAgricultural Research Service, U.S. Department of Agriculture, Beltsville, MD 20705, USA.
Douglas P GladueForeign Animal Disease Research Unit, Plum Island Animal Disease Center, U.S. Department of Agriculture, Agricultural Research Service, Orient, NY 11957, USA.ORCID 0000-0002-7894-0233
Agricultural Research Service · USOak Ridge Associated Universities · USAnimal and Plant Health Inspection Service · US

Funding

Foundation for Food and Agriculture 21-000064National Pork Board 21-137
6 · The paper itself

Abstract

The African swine fever virus (ASFV) mutant ASFV-G-∆I177L is a safe and efficacious vaccine which induces protection against the challenge of its parental virus, the Georgia 2010 isolate. Although a genetic DIVA (differentiation between infected and vaccinated animals) assay has been developed for this vaccine, still there is not a serological DIVA test for differentiating between animals vaccinated with ASFV-G-∆I177L and those infected with wild-type viruses. In this report, we describe the development of the ASFV-G-∆I177L mutant having deleted the

Indexed as

African Swine FeverAfrican Swine Fever VirusViral VaccinesAnimalsGene DeletionRecombinant ProteinsSus scrofaSwineVaccines, AttenuatedVaccines, SyntheticVirulenceRecombinant ProteinsVaccines, AttenuatedVaccines, SyntheticViral VaccinesAfrican swine feverAfrican swine fever virusASF vaccineEp402REP402R marker vaccineI177L

Identifiers

PMID38543742
PMCPMC10974803
OpenAlexW4392233327

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.