Evidence map›Paper›PMID 38543479›Full record

ArticleMicroorganisms2024

Relationship between the Viral Load in Patients with Different COVID-19 Severities and SARS-CoV-2 Variants.

Andrea Santos Coy-Arechavaleta, Julio Elias Alvarado-Yaah, Luis Antonio Uribe-Noguez, Francisco Xavier Guerra-Castillo, Clara Esperanza Santacruz-Tinoco, Eva Ramón-Gallegos, José Esteban Muñoz-Medina, Larissa Fernandes-Matano

Abstract read
In one paragraph

Article in Microorganisms, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Immune Response to Respiratory Viral Infections.International journal of molecular sciences · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Andrea Santos Coy-ArechavaletaEscuela Nacional de Ciencias Biológicas, Programa de Doctorado en Ciencias en Biomedicina y Biotecnología Molecular, Instituto Politécnico Nacional-IPN, Mexico City 11350, Mexico.
Julio Elias Alvarado-YaahLaboratorio Central de Epidemiología, Instituto Mexicano del Seguro Social, Mexico City 02990, Mexico.
Luis Antonio Uribe-NoguezLaboratorio Central de Epidemiología, Instituto Mexicano del Seguro Social, Mexico City 02990, Mexico.ORCID 0000-0003-2452-782X
Francisco Xavier Guerra-CastilloUnidad de Investigación Médica en Inmunología e Infectología "Dr. Daniel Méndez Hernández", La Raza, Instituto Mexicano del Seguro Social, Mexico City 02990, Mexico.ORCID 0000-0002-3346-2004
Clara Esperanza Santacruz-TinocoDivisión de Laboratorios Especializados, Instituto Mexicano del Seguro Social, Mexico City 07760, Mexico.ORCID 0000-0003-0039-986X
Eva Ramón-GallegosEscuela Nacional de Ciencias Biológicas, Programa de Doctorado en Ciencias en Biomedicina y Biotecnología Molecular, Instituto Politécnico Nacional-IPN, Mexico City 11350, Mexico.ORCID 0000-0003-2262-5207
José Esteban Muñoz-MedinaDivisión de Laboratorios Especializados, Instituto Mexicano del Seguro Social, Mexico City 07760, Mexico.ORCID 0000-0002-1289-4457
Larissa Fernandes-MatanoDivisión de Laboratorios Especializados, Instituto Mexicano del Seguro Social, Mexico City 07760, Mexico.ORCID 0000-0001-7599-1046

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

SARS-CoV-2 has spread throughout the world since 2019, changing in its genome and leading to the appearance of new variants. This gave it different evolutionary advantages, such as greater infectivity and/or a greater ability to avoid the immune response, which could lead to an increased severity of COVID-19 cases. There is no consistent information about the viral load that occurs in infection with the different SARS-CoV-2 variants, hence, in this study we quantify the viral load of more than 16,800 samples taken from the Mexican population with confirmed diagnosis of COVID-19 and we analyze the relation between different demographic and disease variables. We detected that the viral load caused by different variants differs only in the first two days after the onset of symptoms, being higher when infections are caused by the delta variant and lower when caused by omicron. Furthermore, the viral load appears to be higher in outpatients compared to hospitalized patients or in cases of death. On the other hand, no differences were found in the viral load produced in vaccinated and unvaccinated patients, nor did it differ between genders.

Indexed as

ddCtoutcome of COVID-19severityviral load

Identifiers

PMID38543479
PMCPMC10972047

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.