Evidence map›Paper›PMID 38543271›Full record

ArticlePharmaceutics2024

pH-Triggered Controlled Release of Chlorhexidine Using Chitosan-Coated Titanium Silica Composite for Dental Infection Prevention.

Mrinal Gaurav Srivastava, Nur Hidayatul Nazirah Kamarudin, Merve Kübra Aktan, Kai Zheng, Naiera Zayed, Derick Yongabi, Patrick Wagner, Wim Teughels, Aldo R Boccaccini, Annabel Braem

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.8field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 4 countries.

Mrinal Gaurav SrivastavaKU Leuven, Department of Materials Engineering (MTM), 3001 Leuven, Belgium.ORCID 0000-0001-9058-3462
Nur Hidayatul Nazirah KamarudinKU Leuven, Department of Materials Engineering (MTM), 3001 Leuven, Belgium.
Merve Kübra AktanKU Leuven, Department of Materials Engineering (MTM), 3001 Leuven, Belgium.
Kai ZhengUniversity of Erlangen-Nuremberg, Department of Materials Science and Engineering, Institute of Biomaterials, 91058 Erlangen, Germany.ORCID 0000-0002-2573-6677
Naiera ZayedKU Leuven, Department of Oral Health Sciences, 3000 Leuven, Belgium.ORCID 0000-0002-7773-8199
Derick YongabiKU Leuven, Department of Physics and Astronomy, Laboratory for Soft Matter and Biophysics, 3001 Leuven, Belgium.ORCID 0000-0003-0615-6455
Patrick WagnerKU Leuven, Department of Physics and Astronomy, Laboratory for Soft Matter and Biophysics, 3001 Leuven, Belgium.ORCID 0000-0002-4028-3629
Wim TeughelsKU Leuven, Department of Oral Health Sciences, 3000 Leuven, Belgium.
Aldo R BoccacciniUniversity of Erlangen-Nuremberg, Department of Materials Science and Engineering, Institute of Biomaterials, 91058 Erlangen, Germany.ORCID 0000-0002-7377-2955
Annabel BraemKU Leuven, Department of Materials Engineering (MTM), 3001 Leuven, Belgium.ORCID 0000-0002-4890-0177
KU Leuven · BEFriedrich-Alexander-Universität Erlangen-Nürnberg · DEGhent University · BENational University of Malaysia · MY

Funding

KU Leuven STG/17/024, C32/18/059
6 · The paper itself

Abstract

Peri-implantitis is a growing pathological concern for dental implants which aggravates the occurrence of revision surgeries. This increases the burden on both hospitals and the patients themselves. Research is now focused on the development of materials and accompanying implants designed to resist biofilm formation. To enhance this endeavor, a smart method of biofilm inhibition coupled with limiting toxicity to the host cells is crucial. Therefore, this research aims to establish a proof-of-concept for the pH-triggered release of chlorhexidine (CHX), an antiseptic commonly used in mouth rinses, from a titanium (Ti) substrate to inhibit biofilm formation on its surface. To this end, a macroporous Ti matrix is filled with mesoporous silica (together referred to as Ti/SiO

Indexed as

biofilm inhibitionchitosanchlorhexidinecontrolled drug releasedental implantmesoporous silicapH responsetitanium

Identifiers

PMID38543271
PMCPMC10974051
OpenAlexW4392596608

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.