A Monocarbonyl Curcuminoid Derivative Inhibits the Activity of Human Glutathione Transferase A4-4 and Chemosensitizes Glioblastoma Cells to Temozolomide.
Article in Pharmaceuticals (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
3 citing papers in PubMed, 4 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
12 authors at 5 institutions in 3 countries.
Steliana TsouriLaboratory of Enzyme Technology, Department of Biotechnology, School Applied Biology and Biotechnology, Agricultural University of Athens, 75 Iera Odos Street, 11855 Athens, Greece.
Evanthia TseloLaboratory of Enzyme Technology, Department of Biotechnology, School Applied Biology and Biotechnology, Agricultural University of Athens, 75 Iera Odos Street, 11855 Athens, Greece.
Georgios E PremetisLaboratory of Enzyme Technology, Department of Biotechnology, School Applied Biology and Biotechnology, Agricultural University of Athens, 75 Iera Odos Street, 11855 Athens, Greece.
Veronika FurlanFaculty of Chemistry and Chemical Engineering, University of Maribor, Smetanova 17, SI-2000 Maribor, Slovenia.
Panagiota D PantioraLaboratory of Enzyme Technology, Department of Biotechnology, School Applied Biology and Biotechnology, Agricultural University of Athens, 75 Iera Odos Street, 11855 Athens, Greece.ORCID 0000-0002-4675-0435
Barbara MavroidiInstitute of Biosciences & Applications, National Centre for Scientific Research "Demokritos", 15310 Athens, Greece.ORCID 0000-0002-4453-5758
Dimitris MatiadisInstitute of Biosciences & Applications, National Centre for Scientific Research "Demokritos", 15310 Athens, Greece.ORCID 0000-0003-0059-952X
Maria PelecanouInstitute of Biosciences & Applications, National Centre for Scientific Research "Demokritos", 15310 Athens, Greece.ORCID 0000-0002-7669-2424
Anastassios C PapageorgiouTurku Bioscience Centre, University of Turku and Åbo Akademi University, 20521 Turku, Finland.ORCID 0000-0002-7980-1120
Urban BrenFaculty of Chemistry and Chemical Engineering, University of Maribor, Smetanova 17, SI-2000 Maribor, Slovenia.
Marina SagnouInstitute of Biosciences & Applications, National Centre for Scientific Research "Demokritos", 15310 Athens, Greece.ORCID 0000-0002-4231-6658
Nikolaos E LabrouLaboratory of Enzyme Technology, Department of Biotechnology, School Applied Biology and Biotechnology, Agricultural University of Athens, 75 Iera Odos Street, 11855 Athens, Greece.ORCID 0000-0003-1925-9867
Agricultural University of Athens · GRNational Centre of Scientific Research "Demokritos" · GRÅbo Akademi University · FIUniversity of Maribor · SIUniversity of Primorska · SI
Funding
Slovenian Ministry of Science and Education NOOSlovenian Research and Innovation Agency (ARIS) program P2-0046, P2-0438, L2-3175, J1-4398, L2-4430, J3-4498, J7-4638, J1-4414, J3-4497, J4-4633, I0-E015, and J1-2471
6 · The paper itself
Abstract
Human glutathione transferase A4-4 (hGSTA4-4) displays high catalytic efficiency towards 4-hydroxyalkenals and other cytotoxic and mutagenic products of radical reactions and lipid peroxidation. Its role as a target for the chemosensitization of cancer cells has not been investigated so far. In this study, the inhibitory potency of twelve selected natural products and ten monocarbonyl curcumin derivatives against hGSTA4-4 was studied. Among natural products, ellagic acid turned out to be the strongest inhibitor with an IC
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
A Monocarbonyl Curcuminoid Derivative Inhibits the Activity of Human Glutathione Transferase A4-4 and Chemosensitizes Glioblastoma Cells to Temozolomide. · full record | OpenQuestion