Evidence map›Paper›PMID 38543114›Full record

ReviewPharmaceuticals (Basel, Switzerland)2024

Marine-Derived Bioactive Metabolites as a Potential Therapeutic Intervention in Managing Viral Diseases: Insights from the SARS-CoV-2 In Silico and Pre-Clinical Studies.

Queency N Okechukwu, Feyisayo O Adepoju, Osman N Kanwugu, Parise Adadi, Ángel Serrano-Aroca, Vladimir N Uversky, Charles Odilichukwu R Okpala

Abstract readReview
In one paragraph

Review in Pharmaceuticals (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Induction of Extrinsic Apoptotic Pathway in Pancreatic Cancer Cells byInternational journal of molecular sciences · 2025
    Article
  5. Article
  6. Review
  7. Antiviral Activity ofInternational journal of molecular sciences · 2024
    Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Queency N OkechukwuInstitute of Chemical Technology, Ural Federal University Named after the First President of Russia B. N. Yeltsin, Mira Street 28, Yekaterinburg 620002, Russia.ORCID 0000-0002-8108-6787
Feyisayo O AdepojuInstitute of Chemical Technology, Ural Federal University Named after the First President of Russia B. N. Yeltsin, Mira Street 28, Yekaterinburg 620002, Russia.ORCID 0000-0002-4777-0825
Osman N KanwuguARC Centre of Excellence in Synthetic Biology, School of Natural Sciences, Macquarie University, Sydney, NSW 2109, Australia.ORCID 0000-0003-3887-1058
Parise AdadiDepartment of Food Science, University of Otago, Dunedin 9054, New Zealand.ORCID 0000-0003-4724-9463
Ángel Serrano-ArocaBiomaterials and Bioengineering Lab, Centro de Investigación Traslacional San Alberto Magno, Universidad Católica de Valencia San Vicente Mártir, 46001 Valencia, Spain.ORCID 0000-0002-9953-3848
Vladimir N UverskyDepartment of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.ORCID 0000-0002-4037-5857
Charles Odilichukwu R OkpalaUGA Cooperative Extension, College of Agricultural and Environmental Sciences, University of Georgia, Athens, GA 30602, USA.ORCID 0000-0003-4475-8887

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Worldwide urbanization and subsequent migration have accelerated the emergence and spread of diverse novel human diseases. Among them, diseases caused by viruses could result in epidemics, typified by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which hit the globe towards the end of December 2019. The global battle against SARS-CoV-2 has reignited interest in finding alternative treatments for viral infections. The marine world offers a large repository of diverse and unique bioactive compounds. Over the years, many antiviral compounds from marine organisms have been isolated and tested in vitro and in vivo. However, given the increasing need for alternative treatment, in silico analysis appears to provide a time- and cost-effective approach to identifying the potential antiviral compounds from the vast pool of natural metabolites isolated from marine organisms. In this perspective review, we discuss marine-derived bioactive metabolites as potential therapeutics for all known disease-causing viruses including the SARS-CoV-2. We demonstrate the efficacy of marine-derived bioactive metabolites in the context of various antiviral activities and their in silico, in vitro, and in vivo capacities.

Indexed as

marine metabolitesmarine organismspandemicSARS-CoV-2therapeuticsviral infectionviruses

Identifiers

PMID38543114
PMCPMC10975954

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.