Evidence map›Paper›PMID 38543043›Full record

ArticleMolecules (Basel, Switzerland)2024

Discovery of Novel 4-Hydroxyquinazoline Derivatives: In Silico, In Vivo and In Vitro Studies Using Primary PARPi-Resistant Cell Lines.

Lijie Zhu, Binzhuo Liu, Feng Jin, Weilong Cao, Guangzhao Xu, Xinwei Zhang, Peng Peng, Dingding Gao, Bin Wang, Kairui Feng

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Lijie ZhuSchool of Pharmacy, Shandong Second Medical University, Weifang 261053, China.
Binzhuo LiuSchool of Pharmacy, Shandong Second Medical University, Weifang 261053, China.
Feng JinSchool of Pharmacy, Shandong Second Medical University, Weifang 261053, China.
Weilong CaoSchool of Pharmacy, Shandong Second Medical University, Weifang 261053, China.
Guangzhao XuSchool of Pharmacy, Shandong Second Medical University, Weifang 261053, China.
Xinwei ZhangSchool of Pharmacy, Shandong Second Medical University, Weifang 261053, China.
Peng PengSchool of Pharmacy (Preparatory), East China Normal University, Shanghai 200241, China.
Dingding GaoThe Research Center of Chiral Drugs, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Bin WangSchool of Pharmacy, Shandong Second Medical University, Weifang 261053, China.
Kairui FengSchool of Pharmacy, Shandong Second Medical University, Weifang 261053, China.
Weifang Medical University · CNEast China Normal University · CNShanghai University of Traditional Chinese Medicine · CN

Funding

National Natural Science Foundation of China 22201218Natural Science Foundation of Shandong Province ZR2022QB198 and ZR2023QB055Overseas Excellent Youth Science Fund project of Shandong Provience 2023HWYQ-095Taishan Scholar Project of Shandong Province tsqn202211366
6 · The paper itself

Abstract

A series of novel 4-Hydroxyquinazoline derivatives were designed and synthesized to enhance sensitivity in primary PARPi-resistant cells. Among them, the compound

Indexed as

Antineoplastic AgentsDrug Resistance, NeoplasmQuinazolinonesCell Line, TumorMolecular Docking Simulation4-hydroxyquinazolineAntineoplastic AgentsQuinazolinones4-Hydroxyquinazolineanti-tumorPARPiprimary drug-resistant

Identifiers

PMID38543043
PMCPMC10974284
OpenAlexW4393039604

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.