Insulin Conformation Changes in Hybrid Alginate-Gelatin Hydrogel Particles.

Gulzhan Ye Yerlan, Michael Shen, Bakyt B Tyussyupova, Sagdat M Tazhibayeva, Kuanyshbek Musabekov, Paul Takhistov

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In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

1.7field-weighted citation impact, top 16% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 10 citations in OpenAlex.

Advancements in insulin delivery: the potential of natural polymers for improved diabetes management.Frontiers in bioengineering and biotechnology · 2025
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Gulzhan Ye YerlanDepartment of Analytical, Colloid Chemistry and Technology of Rare Elements, Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, 71 Al-Farabi Ave., Almaty 050040, Kazakhstan.ORCID 0000-0001-8770-9992

Michael ShenDepartment of Food Science, The State University of New Jersey, 65 Dudley Road, New Brunswick, NJ 08901, USA.

Bakyt B TyussyupovaDepartment of Analytical, Colloid Chemistry and Technology of Rare Elements, Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, 71 Al-Farabi Ave., Almaty 050040, Kazakhstan.ORCID 0000-0001-6149-2326

Sagdat M TazhibayevaDepartment of Analytical, Colloid Chemistry and Technology of Rare Elements, Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, 71 Al-Farabi Ave., Almaty 050040, Kazakhstan.ORCID 0000-0003-3300-3235

Kuanyshbek MusabekovDepartment of Analytical, Colloid Chemistry and Technology of Rare Elements, Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, 71 Al-Farabi Ave., Almaty 050040, Kazakhstan.ORCID 0000-0003-1114-1901

Paul TakhistovDepartment of Food Science, The State University of New Jersey, 65 Dudley Road, New Brunswick, NJ 08901, USA.ORCID 0000-0001-8797-709X

Rutgers, The State University of New Jersey · USAl-Farabi Kazakh National University · KZKazakh-British Technical University · KZ

Funding

Ministry of Science and Higher Education Republic of Kazakhstan AP19677207United States Department of Agriculture NJAES NC 1194

6 · The paper itself

Abstract

There is a strong need to develop an insulin delivery system suitable for oral administration and preserving natural (α-helix) insulin conformation. In this work, we fabricated alginate-gelatin hydrogel beads for insulin encapsulation. Altering matrix composition and crosslinking agents has resulted in various surface morphologies and internal spatial organization. The structures of the insulin-loaded matrices were studied using optical and field emission electronic microscopy. We use FTIR spectroscopy to identify insulin conformation changes as affected by the hydrogel matrices. It was found that blended alginate-gelatin matrices demonstrate better encapsulation efficiency and stronger swelling resistance to a simulated gastric environment than sodium alginate beads crosslinked with the CaCl

Indexed as

HydrogelsInsulinAlginatesGelatinAlginatesGelatinHydrogelsInsulinalginategelatinhydrogel particlesinsulininsulin fibrinogenesis

Identifiers

PMID38542891

DOI10.3390/molecules29061254

PMCPMC10975875

OpenAlexW4392710839

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.