Evidence map›Paper›PMID 38542890›Full record

ArticleMolecules (Basel, Switzerland)2024

One-Step Construction of 1,3,4-Oxadiazoles with Anticancer Activity from Tertiary Amines via a Sequential Copper(I)-Catalyzed Oxidative Ugi/aza-Wittig Reaction.

Mei Sun, Nong-Qi Mao, Sheng-Long Wang, Xin-Ming Han, Gang Yao, Ping Xue, Chong-Yang Zeng, Yu-Ting Liu, Kai Chen, Xiao-Qing Gao and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Mei SunAnhui Key Laboratory of Low Temperature Co-Fired Materials, School of Chemistry and Material Engineering, Huainan Normal University, Huainan 232038, China.ORCID 0009-0001-4590-1465
Nong-Qi MaoSchool of Pharmacy, Xianning Medical College, Hubei University of Science and Technology, Xianning 437100, China.
Sheng-Long WangSchool of Pharmacy, Xianning Medical College, Hubei University of Science and Technology, Xianning 437100, China.
Xin-Ming HanSchool of Pharmacy, Xianning Medical College, Hubei University of Science and Technology, Xianning 437100, China.
Gang YaoSchool of Pharmacy, Xianning Medical College, Hubei University of Science and Technology, Xianning 437100, China.
Ping XueSchool of Pharmacy, Xianning Medical College, Hubei University of Science and Technology, Xianning 437100, China.
Chong-Yang ZengAnhui Key Laboratory of Low Temperature Co-Fired Materials, School of Chemistry and Material Engineering, Huainan Normal University, Huainan 232038, China.
Yu-Ting LiuAnhui Key Laboratory of Low Temperature Co-Fired Materials, School of Chemistry and Material Engineering, Huainan Normal University, Huainan 232038, China.
Kai ChenAnhui Key Laboratory of Low Temperature Co-Fired Materials, School of Chemistry and Material Engineering, Huainan Normal University, Huainan 232038, China.
Xiao-Qing GaoAnhui Key Laboratory of Low Temperature Co-Fired Materials, School of Chemistry and Material Engineering, Huainan Normal University, Huainan 232038, China.
Jun XiongSchool of Pharmacy, Xianning Medical College, Hubei University of Science and Technology, Xianning 437100, China.
Hubei University of Science and Technology · CNHuainan Normal University · CN

Funding

the Doctoral Foundation of Huainan Normal University no. 621217-BSKYQDJthe Hubei Provincial Natural Science Foundation of China no. 2023AFB479the Hubei University of Science and Technology Doctoral Research Initiation Project no. BK202325the Medical Research Project of Hubei University of Science and Technology no. 2022YKY12the Science and Technology Plan Project of Huainan City no. 2023A319
6 · The paper itself

Abstract

An unparalleled copper(I)-catalyzed synthesis of 1,3,4-oxadiazoles from tertiary amines in one step has been described. The one-pot reactions involving (N-isocyanimine)triphenylphosphorane, tertiary amines, and carboxylic acids resulted in the formation of 1,3,4-oxadiazoles in moderate to good yields through a consecutive oxidative Ugi/aza-Wittig reaction, enabling the direct functionalization of sp

Indexed as

CopperOrganophosphorus CompoundsOxadiazolesAminesCatalysisOxidative StressAminesCopperOrganophosphorus CompoundsOxadiazolestriphenylphosphonium1,3,4-oxadiazoleanticanceraza-Wittig reactionC-H functionalizationCu-catalyzedoxidative Ugi reaction

Identifiers

PMID38542890
PMCPMC10975333
OpenAlexW4392710892

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.