Evidence map›Paper›PMID 38542873›Full record

ArticleMolecules (Basel, Switzerland)2024

The Validation and Determination of Empagliflozin Concentration in the Presence of Grapefruit Juice Using HPLC for Pharmacokinetic Applications.

Wael Abu Dayyih, Zainab Zakaraya, Mohammad Hailat, Nafe M Al-Tawarah, Sahem Alkharabsheh, Haya Khalid Nadher, Zeyad Hailat, Samia M Alarman, Anas Khaleel, Riad Awad

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Wael Abu DayyihFaculty of Pharmacy, Mutah University, Al-Karak 61710, Jordan.ORCID 0000-0002-5832-7247
Zainab ZakarayaFaculty of Pharmacy, Al-Ahliyya Amman University, Amman 19328, Jordan.ORCID 0000-0003-3691-9759
Mohammad HailatFaculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman 11733, Jordan.ORCID 0000-0003-4263-0134
Nafe M Al-TawarahFaculty of Allied Medical Sciences, Medical Laboratory Sciences, Mutah University, Al-Karak 61710, Jordan.
Sahem AlkharabshehFaculty of Allied Medical Sciences, Medical Laboratory Sciences, Mutah University, Al-Karak 61710, Jordan.ORCID 0000-0003-4840-3426
Haya Khalid NadherFaculty of Pharmacy and Medical Sciences, University of Petra, Amman 11196, Jordan.
Zeyad HailatDepartment of Information Systems, Yarmouk University, Irbid 21163, Jordan.
Samia M AlarmanFaculty of Pharmacy, Mutah University, Al-Karak 61710, Jordan.
Anas KhaleelFaculty of Pharmacy and Medical Sciences, University of Petra, Amman 11196, Jordan.ORCID 0000-0001-7584-2438
Riad AwadFaculty of Pharmacy and Medical Sciences, University of Petra, Amman 11196, Jordan.
Mutah University · JOPetra University · JOAl-Ahliyya Amman University · JOAl-Zaytoonah University of Jordan · JOYarmouk University · JO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Type 2 diabetes mellitus is a multifactorial disorder whose primary manifestation usually initiates with elevated blood sugar levels. Several antidiabetic agents are used to manage type 2 diabetes mellitus, of which empagliflozin is an oral sodium-glucose co-transporter (SGLT-2) inhibitor in the kidney. This research aims to develop and validate a simple analytical method for determining empagliflozin levels in biological fluid and to further evaluate grapefruit juice's impact on empagliflozin pharmacokinetics in rats. High-Performance Liquid Chromatography (HPLC) was used to establish a simple, rapid, and accurate method for determining empagliflozin levels in rat plasma, in the presence of grapefruit juice. Four groups of rats (

Indexed as

Benzhydryl CompoundsCitrusCitrus paradisiDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 2GlucosidesAnimalsArea Under CurveBeveragesChromatography, High Pressure LiquidRatsBenzhydryl CompoundsempagliflozinGlucosidesempagliflozinpharmacokinetics(SGLT-2) inhibitorsodium-glucose co-transporter inhibitortype 2 diabetes mellitus

Identifiers

PMID38542873
PMCPMC10974941
OpenAlexW4392660120

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.