Evidence map›Paper›PMID 38542719›Full record

SynthesisNutrients2024

Genetically Determined Circulating Lactase/Phlorizin Hydrolase Concentrations and Risk of Colorectal Cancer: A Two-Sample Mendelian Randomization Study.

Sihao Han, Jiemin Yao, Hajime Yamazaki, Samantha A Streicher, Jianyu Rao, Roch A Nianogo, Zuofeng Zhang, Brian Z Huang

Open access · goldAbstract readMeta-Analysis
In one paragraph

Synthesis in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Malícia honey (Frontiers in nutrition · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Sihao HanDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, CA 90095, USA.ORCID 0000-0003-3433-3068
Jiemin YaoDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, CA 90095, USA.
Hajime YamazakiSection of Clinical Epidemiology, Department of Community Medicine, Graduate School of Medicine, Kyoto University, Kyoto 606-8303, Japan.
Samantha A StreicherCancer Epidemiology Division, Population Sciences in the Pacific Program, University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu, HI 96813, USA.
Jianyu RaoDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, CA 90095, USA.
Roch A NianogoDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, CA 90095, USA.
Zuofeng ZhangDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, CA 90095, USA.ORCID 0000-0002-4669-3995
Brian Z HuangNorris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USA.
University of California, Los Angeles · USFukushima Medical University · JPUniversity of Hawaiʻi at Mānoa · USUniversity of Southern California · US

Funding

The 'Career MODE' Program: Careers through Mentoring and training in Omics and Data for Early-stage investigatorsR25GM143298 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI IONITA, IULIANA, RE, DIANE BERENGERE · 2021 to 2025
$2.3M
Multidisciplinary Training in Ethnic Diversity and Cancer DisparitiesT32CA229110 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI HAIMAN, CHRISTOPHER ALAN, LE MARCHAND, LOIC · 2019 to 2023
$2.1M
Integrating epidemiologic, clinical, genomic and metabolomic profiles to predict pancreatic cancer risk in a multiethnic populationR00CA256525 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HUANG, BRIAN · 2023 to 2025
$747k
NCI NIH HHS R00 CA256525NCI NIH HHS R00CA256525NCI NIH HHS T32 CA229110NCI NIH HHS T32CA229110NIGMS NIH HHS R25 GM143298NIGMS NIH HHS R25GM143298
6 · The paper itself

Abstract

Previous research has found that milk is associated with a decreased risk of colorectal cancer (CRC). However, it is unclear whether the milk digestion by the enzyme lactase-phlorizin hydrolase (LPH) plays a role in CRC susceptibility. Our study aims to investigate the direct causal relationship of CRC risk with LPH levels by applying a two-sample Mendelian Randomization (MR) strategy. Genetic instruments for LPH were derived from the Fenland Study, and CRC-associated summary statistics for these instruments were extracted from the FinnGen Study, PLCO Atlas Project, and Pan-UK Biobank. Primary MR analyses focused on a

Indexed as

Colorectal NeoplasmsLactase-Phlorizin HydrolaseHumansMendelian Randomization AnalysisLactase-Phlorizin Hydrolasecolorectal cancerlactase/phlorizin hydrolaselactose non-persistenceMendelian randomizationmilk digestion

Identifiers

PMID38542719
PMCPMC10975724
OpenAlexW4392699116

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.