Evidence map›Paper›PMID 38542673›Full record

Trial reportNutrients2024

The Influence of High-Dose Parenteral Vitamin C on the Incidence and Severity of Postoperative Pulmonary Complications in Cardiac Surgery with Extracorporeal Circulation: A Randomized Controlled Trial.

Milica Karadžić Kočica, Arsen Ristić, Ivan Soldatović, Dejan Lazović, Jelena Čumić, Miloš Grujić, Radmila Karan, Duško Terzić, Ivan Palibrk, Mladen Kočica and 1 more

Open access · goldAbstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Milica Karadžić KočicaDepartment of Anesthesiology, Reanimatology and Intensive Care, Clinic for Cardiac Surgery, University Clinical Centre of Serbia, 11000 Belgrade, Serbia.
Arsen RistićMedical Faculty, University of Belgrade, 11000 Belgrade, Serbia.ORCID 0000-0002-0713-1180
Ivan SoldatovićMedical Faculty, University of Belgrade, 11000 Belgrade, Serbia.ORCID 0000-0003-4893-1683
Dejan LazovićMedical Faculty, University of Belgrade, 11000 Belgrade, Serbia.
Jelena ČumićDepartment of Anesthesiology, Reanimatology and Intensive Care, Clinic for Cardiac Surgery, University Clinical Centre of Serbia, 11000 Belgrade, Serbia.
Miloš GrujićMedical Faculty, University of Belgrade, 11000 Belgrade, Serbia.
Radmila KaranDepartment of Anesthesiology, Reanimatology and Intensive Care, Clinic for Cardiac Surgery, University Clinical Centre of Serbia, 11000 Belgrade, Serbia.ORCID 0000-0002-8713-4356
Duško TerzićMedical Faculty, University of Belgrade, 11000 Belgrade, Serbia.
Ivan PalibrkMedical Faculty, University of Belgrade, 11000 Belgrade, Serbia.
Mladen KočicaClinic for Cardiac Surgery, University Clinical Centre of Serbia, 11000 Belgrade, Serbia.ORCID 0000-0002-1391-5053
Dejan MarkovićDepartment of Anesthesiology, Reanimatology and Intensive Care, Clinic for Cardiac Surgery, University Clinical Centre of Serbia, 11000 Belgrade, Serbia.ORCID 0000-0001-5167-4388
University of Belgrade · RS

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiac surgery (CS) with extracorporeal circulation (ECC), induces intense oxidative stress (OS) and systemic inflammatory response (SIR), which may seriously affect postoperative lung function. We aimed to test if high parenteral (200 mg/kg/24 h) daily doses of Vitamin C (VitC), given within 48 h after the beginning of the operation, may reduce the incidence and severity of postoperative pulmonary complications (PPCs) in CS patients. This single-center, prospective, randomized, single-blinded, interventional trial included 150 patients, assigned to control Group A (

Indexed as

Cardiac Surgical ProceduresSaline SolutionAscorbic AcidExtracorporeal CirculationHumansIncidenceLungPostoperative ComplicationsProspective StudiesAscorbic AcidSaline Solutionascorbic acidcardiac surgeryextracorporeal circulationhigh-doseparenteral administrationpostoperative pulmonary complicationsvitamin C

Identifiers

PMID38542673
PMCPMC10975872
OpenAlexW4392546666

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.