Evidence map›Paper›PMID 38542536›Full record

ReviewInternational journal of molecular sciences2024

Immunotherapy and Cancer: The Multi-Omics Perspective.

Clelia Donisi, Andrea Pretta, Valeria Pusceddu, Pina Ziranu, Eleonora Lai, Marco Puzzoni, Stefano Mariani, Elena Massa, Clelia Madeddu, Mario Scartozzi

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  12. Blocking CCR1Cell communication and signaling : CCS · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Clelia DonisiMedical Oncology Unit, Department of Medical Sciences and Public Health, "Azienda Ospedaliero Universitaria" of Cagliari, University of Cagliari, 09042 Cagliari, Italy.ORCID 0000-0003-4129-3375
Andrea PrettaMedical Oncology Unit, Department of Medical Sciences and Public Health, "Azienda Ospedaliero Universitaria" of Cagliari, University of Cagliari, 09042 Cagliari, Italy.
Valeria PuscedduMedical Oncology Unit, Department of Medical Sciences and Public Health, "Azienda Ospedaliero Universitaria" of Cagliari, University of Cagliari, 09042 Cagliari, Italy.ORCID 0000-0003-4167-9091
Pina ZiranuMedical Oncology Unit, Department of Medical Sciences and Public Health, "Azienda Ospedaliero Universitaria" of Cagliari, University of Cagliari, 09042 Cagliari, Italy.
Eleonora LaiMedical Oncology Unit, Department of Medical Sciences and Public Health, "Azienda Ospedaliero Universitaria" of Cagliari, University of Cagliari, 09042 Cagliari, Italy.ORCID 0000-0002-0275-8187
Marco PuzzoniMedical Oncology Unit, Department of Medical Sciences and Public Health, "Azienda Ospedaliero Universitaria" of Cagliari, University of Cagliari, 09042 Cagliari, Italy.
Stefano MarianiMedical Oncology Unit, Department of Medical Sciences and Public Health, "Azienda Ospedaliero Universitaria" of Cagliari, University of Cagliari, 09042 Cagliari, Italy.
Elena MassaMedical Oncology Unit, Department of Medical Sciences and Public Health, "Azienda Ospedaliero Universitaria" of Cagliari, University of Cagliari, 09042 Cagliari, Italy.
Clelia MadedduMedical Oncology Unit, Department of Medical Sciences and Public Health, "Azienda Ospedaliero Universitaria" of Cagliari, University of Cagliari, 09042 Cagliari, Italy.
Mario ScartozziMedical Oncology Unit, Department of Medical Sciences and Public Health, "Azienda Ospedaliero Universitaria" of Cagliari, University of Cagliari, 09042 Cagliari, Italy.ORCID 0000-0001-5977-5546

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immunotherapies have revolutionized cancer treatment approaches. Because not all patients respond positively to immune therapeutic agents, it represents a challenge for scientists who strive to understand the mechanisms behind such resistance. In-depth exploration of tumor biology, using novel technologies such as omics science, can help decode the role of the tumor immune microenvironment (TIME) in producing a response to the immune blockade strategies. It can also help to identify biomarkers for patient stratification and personalized treatment. This review aims to explore these new models and highlight their possible pivotal role in changing clinical practice.

Indexed as

MultiomicsNeoplasmsBiomarkers, TumorHumansImmunotherapyPrecision MedicineTumor MicroenvironmentBiomarkers, TumorAIbiomarkersimmunotherapymulti-omics sciencestate of the art

Identifiers

PMID38542536
PMCPMC10971308

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.