Evidence map›Paper›PMID 38542520›Full record

ArticleInternational journal of molecular sciences2024

Association of Blast Exposure in Military Breaching with Intestinal Permeability Blood Biomarkers Associated with Leaky Gut.

Qingkun Liu, Zhaoyu Wang, Shengnan Sun, Jeffrey Nemes, Lisa A Brenner, Andrew Hoisington, Maciej Skotak, Christina R LaValle, Yongchao Ge, Walter Carr and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Qingkun LiuJames J. Peters VA Medical Center, Bronx, NY 10468, USA.
Zhaoyu WangJames J. Peters VA Medical Center, Bronx, NY 10468, USA.ORCID 0000-0002-6506-9821
Shengnan SunJames J. Peters VA Medical Center, Bronx, NY 10468, USA.ORCID 0000-0002-6962-583X
Jeffrey NemesWalter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Lisa A BrennerRocky Mountain Mental Illness, Research, Education and Clinical Care, Department of Veterans Affairs, Aurora, CO 80045, USA.
Andrew HoisingtonRocky Mountain Mental Illness, Research, Education and Clinical Care, Department of Veterans Affairs, Aurora, CO 80045, USA.
Maciej SkotakWalter Reed Army Institute of Research, Silver Spring, MD 20910, USA.ORCID 0000-0003-2584-7294
Christina R LaValleWalter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Yongchao GeIcahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Walter CarrWalter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Fatemeh HaghighiJames J. Peters VA Medical Center, Bronx, NY 10468, USA.
James J. Peters VA Medical Center · USWalter Reed Army Institute of Research · USIcahn School of Medicine at Mount Sinai · USMental Illness Research, Education and Clinical Centers · USWright-Patterson Air Force Base · US

Funding

Neuroinflammatory and Epigenetic Mechanisms of Blood-Brain Barrier Compromise in SuicideI01BX003794 · VA · JAMES J PETERS VA MEDICAL CENTER · PI HAGHIGHI, FATEMEH G · 2018 to 2024
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DNA Methylation and Inflammatory Signatures Associated with Suicide Risk and Treatment in US VeteransI01CX001395 · VA · JAMES J PETERS VA MEDICAL CENTER · PI HAGHIGHI, FATEMEH G · 2017 to 2023
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Identifying Bio-signatures of Suicidal Subtypes in VeteransI01CX001728 · VA · JAMES J PETERS VA MEDICAL CENTER · PI HAGHIGHI, FATEMEH G · 2019 to 2023
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Identifying DNA Methylation Alterations of Chronic Effects Of Blast and Disturbed SleepI01RX003818 · VA · JAMES J PETERS VA MEDICAL CENTER · PI FATEMEH G HAGHIGHI · 2022 to 2026
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CSR&D Research Career Scientist Award ApplicationIK6CX002074 · VA · JAMES J PETERS VA MEDICAL CENTER · PI HAGHIGHI, FATEMEH G · 2020 to 2025
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BLRD VA I01 BX003794CSRD VA I01 CX001395CSRD VA I01 CX001728CSRD VA IK6 CX002074RRD VA I01 RX003818
6 · The paper itself

Abstract

Injuries and subclinical effects from exposure to blasts are of significant concern in military operational settings, including tactical training, and are associated with self-reported concussion-like symptomology and physiological changes such as increased intestinal permeability (IP), which was investigated in this study. Time-series gene expression and IP biomarker data were generated from "breachers" exposed to controlled, low-level explosive blast during training. Samples from 30 male participants at pre-, post-, and follow-up blast exposure the next day were assayed via RNA-seq and ELISA. A battery of symptom data was also collected at each of these time points that acutely showed elevated symptom reporting related to headache, concentration, dizziness, and taking longer to think, dissipating ~16 h following blast exposure. Evidence for bacterial translocation into circulation following blast exposure was detected by significant stepwise increase in microbial diversity (measured via alpha-diversity

Indexed as

Blast InjuriesBrain ConcussionMilitary PersonnelBiomarkersHumansIntestinal Barrier FunctionMaleBiomarkersblastbrain–gut axisintestinal permeabilityleaky gutmicrobiomemilitarymTBI

Identifiers

PMID38542520
PMCPMC10971443
OpenAlexW4393040157

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.