Evidence map›Paper›PMID 38542395›Full record

ArticleInternational journal of molecular sciences2024

Mitochondrial Dysfunction Causes Cell Death in Patients Affected by Fragile-X-Associated Disorders.

Martina Grandi, Chiara Galber, Cristina Gatto, Veronica Nobile, Cecilia Pucci, Ida Schaldemose Nielsen, Francesco Boldrin, Giovanni Neri, Pietro Chiurazzi, Giancarlo Solaini and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Martina GrandiDepartment of Biomedical and Neuromotor Sciences, University of Bologna, 40126 Bologna, Italy.ORCID 0000-0002-5203-3416
Chiara GalberDepartment of Biomedical and Neuromotor Sciences, University of Bologna, 40126 Bologna, Italy.
Cristina GattoDepartment of Biomedical and Neuromotor Sciences, University of Bologna, 40126 Bologna, Italy.ORCID 0000-0003-1658-8470
Veronica NobileDepartment of Life Sciences and Public Health, Catholic University of Sacred Heart, 00168 Rome, Italy.
Cecilia PucciDepartment of Life Sciences and Public Health, Catholic University of Sacred Heart, 00168 Rome, Italy.
Ida Schaldemose NielsenDepartment of Biomedical and Neuromotor Sciences, University of Bologna, 40126 Bologna, Italy.ORCID 0009-0008-7981-3675
Francesco BoldrinDepartment of Biology, University of Padova, 35121 Padova, Italy.ORCID 0000-0002-0234-2587
Giovanni NeriDepartment of Life Sciences and Public Health, Catholic University of Sacred Heart, 00168 Rome, Italy.
Pietro ChiurazziDepartment of Life Sciences and Public Health, Catholic University of Sacred Heart, 00168 Rome, Italy.ORCID 0000-0001-5104-1521
Giancarlo SolainiDepartment of Biomedical and Neuromotor Sciences, University of Bologna, 40126 Bologna, Italy.ORCID 0000-0001-7825-0446
Alessandra BaraccaDepartment of Biomedical and Neuromotor Sciences, University of Bologna, 40126 Bologna, Italy.ORCID 0000-0002-0490-1776
Valentina GiorgioDepartment of Biomedical and Neuromotor Sciences, University of Bologna, 40126 Bologna, Italy.ORCID 0000-0002-4229-3054
Elisabetta TabolacciDepartment of Life Sciences and Public Health, Catholic University of Sacred Heart, 00168 Rome, Italy.ORCID 0000-0002-4707-2242
Università Cattolica del Sacro Cuore · ITUniversity of Bologna · ITNeuroscience Institute · ITUniversity of Padua · IT

Funding

Fondazione Italiana per la Ricerca sul Cancro, AIRC MFAG 2017 - ID. 20316 (to VG)Ministero dell'Università e della Ricerca PRIN 2017 - ID. 201789LFKB (to VG and ET)
6 · The paper itself

Abstract

Mitochondria are involved in multiple aspects of neurodevelopmental processes and play a major role in the pathogenetic mechanisms leading to neuro-degenerative diseases. Fragile-X-related disorders (FXDs) are genetic conditions that occur due to the dynamic expansion of CGG repeats of the

Indexed as

Fragile X SyndromeIntellectual DisabilityMitochondrial DiseasesCell DeathFragile X Messenger Ribonucleoprotein 1HumansMutationTrinucleotide Repeat ExpansionFMR1 protein, humanFragile X Messenger Ribonucleoprotein 1apoptosisATP synthasedonut-shape mitochondriafragile-X-related disorders (FXDs)neurodegenerationpermeability transition pore

Identifiers

PMID38542395
PMCPMC10970216
OpenAlexW4392917505

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.