Evidence map›Paper›PMID 38542303›Full record

ArticleInternational journal of molecular sciences2024

Antibacterial Properties of Rose Bengal Conjugated to Hyaluronic Acid.

Melad Atrash, Iryna Hovor, Yanna Gurianov, Margarita Barel, Olga Semenova, Tamara Brider, Marina Nisnevitch, Faina Nakonechny

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Melad AtrashDepartment of Chemical Engineering, Ariel University, Kiryat-ha-Mada, Ariel 4070000, Israel.
Iryna HovorDepartment of Chemical Engineering, Ariel University, Kiryat-ha-Mada, Ariel 4070000, Israel.
Yanna GurianovDepartment of Chemical Engineering, Ariel University, Kiryat-ha-Mada, Ariel 4070000, Israel.ORCID 0000-0003-4525-4189
Margarita BarelDepartment of Chemical Engineering, Ariel University, Kiryat-ha-Mada, Ariel 4070000, Israel.
Olga SemenovaDepartment of Chemical Engineering, Ariel University, Kiryat-ha-Mada, Ariel 4070000, Israel.
Tamara BriderDepartment of Chemical Engineering, Ariel University, Kiryat-ha-Mada, Ariel 4070000, Israel.
Marina NisnevitchDepartment of Chemical Engineering, Ariel University, Kiryat-ha-Mada, Ariel 4070000, Israel.ORCID 0000-0001-8493-713X
Faina NakonechnyDepartment of Chemical Engineering, Ariel University, Kiryat-ha-Mada, Ariel 4070000, Israel.ORCID 0000-0002-8973-1322
Ariel University · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dental diseases, including conditions affecting oral structures, have become more common due to unhealthy lifestyle choices. Traditional antibiotic treatments face challenges related to the development of antibiotic resistance in bacteria. Photodynamic antibacterial chemotherapy is emerging as a promising alternative using photosensitizers to generate reactive oxygen species upon exposure to light. This article examines the photosensitizer Rose Bengal (RB) immobilized in hyaluronic acid (HA) for prolonged antibacterial action. The RB-HA conjugate demonstrated a molar ratio of approximately three RB residues to each of the ten units of HA. RB-HA exhibited a high singlet oxygen quantum yield (ΔΦ = 0.90), suggesting its efficacy in photodynamic treatment. A photostability analysis revealed slower photobleaching of RB-HA, which is essential for prolonged application. Under visible light and ultrasonic treatment, RB-HA exhibited effective antibacterial activity against Gram-positive

Indexed as

PhotochemotherapyRose BengalAnti-Bacterial AgentsEscherichia coliGram-Negative BacteriaHyaluronic AcidPhotosensitizing AgentsStaphylococcus aureusAnti-Bacterial AgentsHyaluronic AcidPhotosensitizing AgentsRose BengalconjugationE. colihyaluronic acidphotodynamic antibacterial activityrose bengalS. aureusslow drug releasesonodynamic antibacterial activity

Identifiers

PMID38542303
PMCPMC10970196
OpenAlexW4392847675

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.