Evidence map›Paper›PMID 38542204›Full record

ArticleInternational journal of molecular sciences2024

Identification of Genetic Variants for Risk Prediction and Early Diagnosis of Age-Related Macular Degeneration in the Taiwanese Population.

Yu-Chuen Huang, Wen-Ling Liao, Hui-Ju Lin, Yu-Te Huang, Ya-Wen Chang, Ting-Yuan Liu, Yu-Chia Chen, Angel L Weng, Fuu-Jen Tsai

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Yu-Chuen HuangSchool of Chinese Medicine, China Medical University, Taichung 404328, Taiwan.
Wen-Ling LiaoCenter for Personalized Medicine, China Medical University Hospital, Taichung 404327, Taiwan.ORCID 0000-0003-1223-8844
Hui-Ju LinSchool of Chinese Medicine, China Medical University, Taichung 404328, Taiwan.
Yu-Te HuangDepartment of Ophthalmology, China Medical University Hospital, Taichung 404327, Taiwan.ORCID 0000-0002-9246-8756
Ya-Wen ChangGenetic Center, Department of Medical Research, China Medical University Hospital, Taichung 404327, Taiwan.
Ting-Yuan LiuMillion-Person Precision Medicine Initiative, Department of Medical Research, China Medical University Hospital, Taichung 404327, Taiwan.ORCID 0000-0002-2729-0541
Yu-Chia ChenMillion-Person Precision Medicine Initiative, Department of Medical Research, China Medical University Hospital, Taichung 404327, Taiwan.
Angel L WengAmerican School in Taichung, Taichung 406051, Taiwan.
Fuu-Jen TsaiSchool of Chinese Medicine, China Medical University, Taichung 404328, Taiwan.
China Medical University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly worldwide. The prevalence and phenotypes of AMD differ among populations, including between people in Taiwan and other regions. We performed a genome-wide association study to identify genetic variants and to develop genetic models to predict the risk of AMD development and progression in the Taiwanese population. In total, 4039 patients with AMD and 16,488 non-AMD controls (aged ≥ 65 years) were included. We identified 31 AMD-associated variants (

Indexed as

Macular DegenerationProteinsAgedEarly DiagnosisGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHigh-Temperature Requirement A Serine Peptidase 1HumansPolymorphism, Single NucleotideRisk FactorsHigh-Temperature Requirement A Serine Peptidase 1Proteinsage-related macular degenerationgenome-wide association studypolygenic risk score

Identifiers

PMID38542204
PMCPMC10970312
OpenAlexW4392699292

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.