Evidence map›Paper›PMID 38542181›Full record

ArticleInternational journal of molecular sciences2024

Identifying Differences in Molecular Characteristics Relevant for Remodeling of Periodontal Ligament Stem Cells from the Upper and Lower Jaw.

Hanna Malyaran, Rogerio B Craveiro, Sinan Mert, Christian Niederau, Sanne L Maas, Emiel P C van der Vorst, Frank Hölzle, Wilhelm Jahnen-Dechent, Michael Wolf, Sabine Neuss

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Hanna MalyaranInterdisciplinary Center for Clinical Research (IZKF), RWTH Aachen University, 52074 Aachen, Germany.ORCID 0000-0002-5992-510X
Rogerio B CraveiroDepartment of Orthodontics, University Hospital of RWTH Aachen, 52074 Aachen, Germany.ORCID 0000-0003-0768-935X
Sinan MertDivision of Hand, Plastic and Aesthetic Surgery, LMU University Hospital Munich, 80336 Munich, Germany.
Christian NiederauDepartment of Orthodontics, University Hospital of RWTH Aachen, 52074 Aachen, Germany.
Sanne L MaasInterdisciplinary Center for Clinical Research (IZKF), RWTH Aachen University, 52074 Aachen, Germany.ORCID 0000-0003-1423-8901
Emiel P C van der VorstInterdisciplinary Center for Clinical Research (IZKF), RWTH Aachen University, 52074 Aachen, Germany.ORCID 0000-0001-5771-6278
Frank HölzleDepartment of Oral and Maxillofacial Surgery, University Hospital of RWTH Aachen, 52074 Aachen, Germany.
Wilhelm Jahnen-DechentBioInterface Group, Helmholtz Institute for Biomedical Engineering, RWTH Aachen University, 52056 Aachen, Germany.ORCID 0000-0003-1315-4407
Michael WolfDepartment of Orthodontics, University Hospital of RWTH Aachen, 52074 Aachen, Germany.
Sabine NeussBioInterface Group, Helmholtz Institute for Biomedical Engineering, RWTH Aachen University, 52056 Aachen, Germany.
RWTH Aachen University · DELMU Klinikum · DELudwig-Maximilians-Universität München · DE

Funding

Deutsche Forschungsgemeinschaft NE1650/9-1 and WO2031/5-1Interdisciplinary Centre for Clinical Research within the faculty of Medicine at the RWTH Aachen University OC1-3 and E.P.C.v.d.V.
6 · The paper itself

Abstract

Periodontal defects' localization affects wound healing and bone remodeling, with faster healing in the upper jaw compared to the lower jaw. While differences in blood supply, innervation, and odontogenesis contribute, cell-intrinsic variances may exist. Few studies explored cell signaling in periodontal ligament stem cells (PDLSC), overlooking mandible-maxilla disparitiesUsing kinomics technology, we investigated molecular variances in PDLSC. Characterization involved stem cell surface markers, proliferation, and differentiation capacities. Kinase activity was analyzed via multiplex kinase profiling, mapping differential activity in known gene regulatory networks. Upstream kinase analysis identified stronger EphA receptor expression in the mandible, potentially inhibiting osteogenic differentiation. The PI3K-Akt pathway showed higher activity in lower-jaw PDLSC. PDLSC from the upper jaw exhibit superior proliferation and differentiation capabilities. Differential activation of gene regulatory pathways in upper vs. lower-jaw PDLSC suggests implications for regenerative therapies.

Indexed as

OsteogenesisPeriodontal LigamentCell DifferentiationCell ProliferationCells, CulturedMandiblePhosphatidylinositol 3-KinasesStem CellsPhosphatidylinositol 3-Kinaseskinase activitymandiblemaxillaperiodontal ligament stem cellsserine/threoninetyrosine

Identifiers

PMID38542181
PMCPMC10969799
OpenAlexW4392780816

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.