Evidence map›Paper›PMID 38542137›Full record

ArticleInternational journal of molecular sciences2024

Surface Topography, Microbial Adhesion, and Immune Responses in Silicone Mammary Implant-Associated Capsular Fibrosis.

Ines Schoberleitner, Leoni Baier, Michaela Lackner, Lisa-Maria Zenz, Débora C Coraça-Huber, Wendy Ullmer, Annabelle Damerum, Klaus Faserl, Stephan Sigl, Theresia Steinkellner and 5 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 4 citations in OpenAlex.

  1. Observational
  2. Review
  3. Review
  4. Review
  5. Adhesion and Colonization Intensity ofJournal of functional biomaterials · 2025
    Article
  6. Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Ines SchoberleitnerDepartment of Plastic, Reconstructive and Aesthetic Surgery, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0001-7988-722X
Leoni BaierDepartment of Plastic, Reconstructive and Aesthetic Surgery, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Michaela LacknerInstitute of Hygiene and Medical Microbiology, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0001-9073-2886
Lisa-Maria ZenzInstitute of Hygiene and Medical Microbiology, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Débora C Coraça-HuberBIOFILM Lab, Department of Orthopedics and Traumatology, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0001-7664-5989
Wendy UllmerZymo Research Corp., Irvine, CA 92614, USA.
Annabelle DamerumZymo Research Corp., Irvine, CA 92614, USA.
Klaus FaserlProtein Core Facility, Institute of Medical Chemistry, Biocenter, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0003-1646-3256
Stephan SiglDepartment of Plastic, Reconstructive and Aesthetic Surgery, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Theresia SteinkellnerDepartment of Plastic, Reconstructive and Aesthetic Surgery, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Selina WinkelmannDepartment of Plastic, Reconstructive and Aesthetic Surgery, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Bettina SargProtein Core Facility, Institute of Medical Chemistry, Biocenter, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Daniel EgleDepartment of Obstetrics and Gynecology, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Christine BrunnerDepartment of Obstetrics and Gynecology, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Dolores WolframDepartment of Plastic, Reconstructive and Aesthetic Surgery, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0003-0920-7211
Innsbruck Medical University · AT

Funding

Establishment Labs; Costa Rica D152000-015-015
6 · The paper itself

Abstract

Breast cancer is the most common cancer in women globally, often necessitating mastectomy and subsequent breast reconstruction. Silicone mammary implants (SMIs) play a pivotal role in breast reconstruction, yet their interaction with the host immune system and microbiome remains poorly understood. This study investigates the impact of SMI surface topography on host antimicrobial responses, wound proteome dynamics, and microbial colonization. Biological samples were collected from ten human patients undergoing breast reconstruction with SMIs. Mass spectrometry profiles were analyzed for acute and chronic wound proteomes, revealing a nuanced interplay between topography and antimicrobial response proteins.

Indexed as

Anti-Infective AgentsBreast ImplantsBreast NeoplasmsFemaleFibrosisHumansMastectomyProteomeRNA, Ribosomal, 16SSiliconesAnti-Infective AgentsProteomeRNA, Ribosomal, 16SSiliconesacute wound proteomeantimicrobial humoral responsecapsular fibrosischronic wound proteomeforeign body response (FBR)immunomicsimplant-associated biofilm formationimplant-based breast reconstructionSMI-adhesive microbiomeSMI surface roughnessSMI topography-specific antimicrobial responseStaphylococcus transmission at surgical sitesurgical site microbiome

Identifiers

PMID38542137
PMCPMC10969816
OpenAlexW4392647442

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.