Evidence map›Paper›PMID 38541774›Full record

ArticleJournal of clinical medicine2024

Paradoxical Changes: EMMPRIN Tissue and Plasma Levels in Marfan Syndrome-Related Thoracic Aortic Aneurysms.

Kyle C Alexander, Carlton W Anderson, Chris B Agala, Panagiotis Tasoudis, Elizabeth N Collins, Yiwen Ding, John W Blackwell, Danielle E Willcox, Behzad S Farivar, Melina R Kibbe and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. The role of MMPs in intracerebral hemorrhage.Frontiers in cell and developmental biology · 2025
    Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Kyle C AlexanderDepartment of Surgery, Division of Cardiothoracic Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Carlton W AndersonAdvanced Analytics Core, Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.
Chris B AgalaDepartment of Surgery, Division of Cardiothoracic Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0000-0001-7157-814X
Panagiotis TasoudisDepartment of Surgery, Division of Cardiothoracic Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Elizabeth N CollinsDepartment of Surgery, Division of Cardiothoracic Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Yiwen DingDepartment of Surgery, Division of Cardiothoracic Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
John W BlackwellDepartment of Surgery, Division of Cardiothoracic Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Danielle E WillcoxDepartment of Surgery, Division of Cardiothoracic Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Behzad S FarivarDepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA.
Melina R KibbeDepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA.
John S IkonomidisDepartment of Surgery, Division of Cardiothoracic Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Adam W AkermanDepartment of Surgery, Division of Cardiothoracic Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0000-0002-8117-0591
University of North Carolina at Chapel Hill · USUniversity of Virginia · US

Funding

PILOT AND FEASIBILITY STUDIESP30DK034987 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ROBERT S. SANDLER · 1985 to 2026
$30.5M
Transmembrane Proteolytic Induction and Thoracic AneurysmsR01HL102121 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI IKONOMIDIS, JOHN S · 2011 to 2019
$3.0M
Enhanced Biochemical Monitoring for Aortic Aneurysm DiseaseR01HL169390 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Adam William Akerman · 2023 to 2026
$2.6M
Device-Based Pathway Intervention: Mechanistic Study of Cellular Localization of Proteolytic Enzymes in Thoracic Aortic Aneurysm DiseaseR56HL161454 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI IKONOMIDIS, JOHN S · 2022 to 2022
$686k
Exploration of key proteases and validation of biomarkers in genetically triggered thoracic aortic aneurysmsR21HL148363 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI IKONOMIDIS, JOHN S · 2019 to 2020
$233k
NHLBI NIH HHS R01 HL102121NHLBI NIH HHS R01 HL169390NHLBI NIH HHS R21 HL148363NHLBI NIH HHS R56 HL161454NIDDK NIH HHS P30 DK034987NIH HHS HL169390
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

EMMPRINMarfan syndromeMT1-MMPthoracic aortic aneurysm

Identifiers

PMID38541774
PMCPMC10970932
OpenAlexW4392588914

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.