Evidence map›Paper›PMID 38541766›Full record

ReviewJournal of clinical medicine2024

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Peter Pressman, A Wallace Hayes, Julia Hoeng, Diogo A R S Latino, Anatoly Mazurov, Walter K Schlage, Azhar Rana

Open access · goldAbstract readReview
In one paragraph

Review in Journal of clinical medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 6 citations in OpenAlex.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Peter PressmanMedicine and Social Sciences, The University of Maine, Orono, ME 04469, USA.
A Wallace HayesCollege of Public Health, University of South Florida, Tampa, FL 33620, USA.
Julia HoengVectura Fertin Pharma, 4058 Basel, Switzerland.
Diogo A R S LatinoRosa Serra Latino Consulting, 6300 Zug, Switzerland.
Anatoly MazurovPositum Consulting, Greensboro, NC 27412, USA.
Walter K SchlageIndependent Researcher, 51429 Bergisch Gladbach, Germany.
Azhar RanaVectura Fertin Pharma, 4058 Basel, Switzerland.
Novartis (Switzerland) · CHFederal Highway Research Institute · DEUniversity of Maine · USUniversity of South Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this overview, we seek to appraise recent experimental and observational studies investigating THC and its potential role as adjunctive therapy in various medical illnesses. Recent clinical trials are suggestive of the diverse pharmacologic potentials for THC but suffer from small sample sizes, short study duration, failure to address tolerance, little dose variation, ill-defined outcome measures, and failure to identify and/or evaluate confounds, all of which may constitute significant threats to the validity of most trials. However, the existing work underscores the potential therapeutic value of THC and, at the same time, calls attention to the critical need for better-designed protocols to fully explore and demonstrate safety and efficacy. In the most general sense, the present brief review illuminates some intriguing findings about THC, along with the basic threats to the validity of the research that supports those findings. The intent is to highlight existing generic weaknesses in the existing randomized controlled trial literature and, most importantly, provide guidance for improved clinical research.

Indexed as

clinical researchclinical trialsΔ9-Tetrahydrocannabinol (THC)

Identifiers

PMID38541766
PMCPMC10971680
OpenAlexW4392549144

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.