Evidence map›Paper›PMID 38541022›Full record

ArticleJournal of personalized medicine2024

Fasting GLP-1 Levels and Albuminuria Are Negatively Associated in Patients with Type 2 Diabetes Mellitus.

Cheol-Won Jang, Tae Yang Yu, Jin Woo Jeong, Se Eun Ha, Rajan Singh, Moon Young Lee, Seungil Ro

Open access · goldAbstract read
In one paragraph

Article in Journal of personalized medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Cheol-Won JangDivision of Endocrinology and Metabolism, Department of Medicine, School of Medicine, Wonkwang University, Iksan 54538, Republic of Korea.
Tae Yang YuDivision of Endocrinology and Metabolism, Department of Medicine, School of Medicine, Wonkwang University, Iksan 54538, Republic of Korea.ORCID 0000-0003-0893-592X
Jin Woo JeongDivision of Endocrinology and Metabolism, Department of Medicine, School of Medicine, Wonkwang University, Iksan 54538, Republic of Korea.
Se Eun HaDepartment of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, NV 89557, USA.ORCID 0000-0001-6063-5559
Rajan SinghDepartment of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, NV 89557, USA.ORCID 0000-0001-5500-1949
Moon Young LeeDepartment of Physiology, School of Medicine, Wonkwang University, Iksan 54538, Republic of Korea.
Seungil RoDepartment of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, NV 89557, USA.ORCID 0000-0003-0861-8334
University of Nevada, Reno · USWonkwang University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glucagon-like peptide-1 (GLP-1) is an incretin hormone known for its pivotal role in enhancing insulin secretion and reducing glucagon release from the pancreas. Diabetic nephropathy, which is characterized by albuminuria, represents a significant microvascular complication of diabetes. Most of the previous studies mainly focused on the therapeutic renal protective effect in clinical trials after the administration of GLP-1 receptor agonists (GLP-1 RAs), rather than before administration. Hence, this study aimed to investigate the association between fasting plasma GLP-1 levels and albuminuria before GLP-1 RA administration. A cross-sectional study was designed to evaluate the association between fasting plasma GLP-1 levels and albuminuria in patients with type 2 diabetes mellitus (T2DM). A cohort of 68 participants with T2DM was analyzed using data collected at Wonkwang University Hospital in Iksan, Korea. Logistic regression analysis was employed to determine the odds ratio (OR) and 95% confidence interval (CI) of the incidence of albuminuria between two groups categorized by fasting GLP-1 levels, low (Group L) and high GLP-1 (Group H). The OR (95% CI) for the incidence of albuminuria comparing Group L with Group H of fasting plasma GLP-1 levels was 3.41 (1.16-10.02),

Indexed as

albuminuriaglucagon-like peptide-1type 2 diabetes mellitus

Identifiers

PMID38541022
PMCPMC10971117
OpenAlexW4392388224

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.