Evidence map›Paper›PMID 38540825›Full record

ArticleFoods (Basel, Switzerland)2024

Characterization of Nanovesicles Isolated from Olive Vegetation Water.

Sandra Buratta, Raffaella Latella, Elisabetta Chiaradia, Anna Maria Salzano, Brunella Tancini, Roberto Maria Pellegrino, Lorena Urbanelli, Giada Cerrotti, Eleonora Calzoni, Husam B R Alabed and 5 more

Open access · goldAbstract read
In one paragraph

Article in Foods (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 12 citations in OpenAlex.

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  8. Nanovesicles fromPharmaceuticals (Basel, Switzerland) · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Sandra BurattaDepartment of Chemistry, Biology and Biotechnology, University of Perugia, 06100 Perugia, Italy.
Raffaella LatellaDepartment of Chemistry, Biology and Biotechnology, University of Perugia, 06100 Perugia, Italy.
Elisabetta ChiaradiaDepartment of Veterinary Medicine, University of Perugia, 06100 Perugia, Italy.ORCID 0000-0002-0958-9187
Anna Maria SalzanoProteomics, Metabolomics and Mass Spectrometry Laboratory, Institute for the Animal Production System in the Mediterranean Environment (ISPAAM), National Research Council, 80055 Portici, Italy.ORCID 0000-0001-7192-8760
Brunella TanciniDepartment of Chemistry, Biology and Biotechnology, University of Perugia, 06100 Perugia, Italy.
Roberto Maria PellegrinoDepartment of Chemistry, Biology and Biotechnology, University of Perugia, 06100 Perugia, Italy.ORCID 0000-0001-5594-383X
Lorena UrbanelliDepartment of Chemistry, Biology and Biotechnology, University of Perugia, 06100 Perugia, Italy.ORCID 0000-0003-0621-8476
Giada CerrottiDepartment of Chemistry, Biology and Biotechnology, University of Perugia, 06100 Perugia, Italy.
Eleonora CalzoniDepartment of Chemistry, Biology and Biotechnology, University of Perugia, 06100 Perugia, Italy.ORCID 0000-0002-2876-952X
Husam B R AlabedDepartment of Chemistry, Biology and Biotechnology, University of Perugia, 06100 Perugia, Italy.ORCID 0000-0002-9229-088X
Sabrina De PascaleProteomics, Metabolomics and Mass Spectrometry Laboratory, Institute for the Animal Production System in the Mediterranean Environment (ISPAAM), National Research Council, 80055 Portici, Italy.
Luana LuginiDepartment of Oncology and Molecular Medicine, Preclinical Research and Clinical Trials in Hematology and Oncology Unit, Istituto Superiore di Sanità, 00161 Rome, Italy.ORCID 0000-0002-8778-2601
Cristina FedericiDepartment of Oncology and Molecular Medicine, Preclinical Research and Clinical Trials in Hematology and Oncology Unit, Istituto Superiore di Sanità, 00161 Rome, Italy.
Andrea ScaloniProteomics, Metabolomics and Mass Spectrometry Laboratory, Institute for the Animal Production System in the Mediterranean Environment (ISPAAM), National Research Council, 80055 Portici, Italy.
Carla EmilianiDepartment of Chemistry, Biology and Biotechnology, University of Perugia, 06100 Perugia, Italy.
University of Perugia · ITIstituto per il Sistema Produzione Animale in Ambiente Mediterraneo · ITIstituto Superiore di Sanità · IT

Funding

Agritech National Research Center funded within the European Union NextGenerationEU program CN00000022European Union - NextGenerationEU under the Italian Ministry of University and Research (MUR) National Innovation Ecosystem grant ECS00000041 - VITALITY. ECS00000041National Recovery and Resilience Plan, mission 4, component 2, investment 1.3, call n. 341/2022 of Italian Ministry of University and Research funded by the European Union - NextGenerationEU for the project "ON Foods - Research and innovation network on f PE00000003
6 · The paper itself

Abstract

Edible plant and fruit-derived nanovesicles (NVs) are membrane-enclosed particles with round-shape morphology and signaling functions, which resemble mammalian cell-derived extracellular vesicles. These NVs can transmit cross-kingdom signals as they contain bioactive molecules and exert biological effects on mammalian cells. Their properties and stability in the gastrointestinal tract suggest NVs as a promising nutraceutical tool. In this study, we have demonstrated for the first time the presence of NVs in olive vegetation water (OVW), a waste by-product generated during olive oil production. Biophysical characterization by scanning electron microscopy, cryo-transmission electron microscopy, and nanoparticle tracking analysis revealed the presence in OVW of NVs having size and morphology similar to that of vesicles isolated from edible plants. Integrated lipidomic, metabolomic, and proteomic analyses showed that OVW-NVs carry a set of lipids, metabolites and proteins which have recognized antioxidant and anti-inflammatory activities. The nature of biomolecules identified in OVW-NVs suggests that these vesicles could exert beneficial effects on mammalian cells and could be used in the nutraceutical and food industries. The successful isolation of OVW-NVs and the characterization of their features strengthen the idea that agricultural waste might represent a source of NVs having features similar to NVs isolated from edible plants/fruits.

Indexed as

edible plant/fruit-derived extracellular vesicleslipidomicsmetabolomicsnanovesiclesolive vegetation waterproteomics

Identifiers

PMID38540825
PMCPMC10968891
OpenAlexW4392601287

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.