Molecular Profiling of Axial Spondyloarthritis Patients Reveals an Association between Innate and Adaptive Cell Populations and Therapeutic Response to Tumor Necrosis Factor Inhibitors.
Article in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
1 citing paper in PubMed, 2 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
18 authors at 9 institutions in 3 countries.
Daniel SobralApplied Molecular Biosciences Unit, Life Sciences Department, Sciences and Technology School, NOVA University of Lisbon, 2829-516 Caparica, Portugal.ORCID 0000-0003-3955-0117
Ana Filipa FernandesInstituto de Tecnologia Química e Biológica António Xavier, Nova University of Lisbon, Av. Da República, 2780-157 Oeiras, Portugal.ORCID 0000-0002-5579-2629
Miguel BernardesDepartment of Medicine, Faculty of Medicine, University of Porto, 4099-002 Porto, Portugal.ORCID 0000-0002-1849-5465
Patrícia PintoRheumatology Department, Centro Hospitalar de Vila Nova de Gaia/Espinho, 4434-502 Vila Nova de Gaia, Portugal.
Helena SantosNOVA Medical Research, NOVA Medical School, NOVA University of Lisbon, 1169-056 Lisbon, Portugal.
João Lagoas-GomesRheumatology Department, Centro Hospitalar do Tâmega e Sousa, Hospital Padre Américo, 4560-136 Penafiel, Portugal.ORCID 0000-0002-3529-1982
José Tavares-CostaRheumatology Department, Unidade Local de Saúde do Alto Minho, 4990-078 Ponte de Lima, Portugal.
José A P SilvaI.CBR-Institute for Clinical and Biomedical Research, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal.
João Madruga DiasNOVA Medical Research, NOVA Medical School, NOVA University of Lisbon, 1169-056 Lisbon, Portugal.ORCID 0000-0001-8956-8492
Alexandra BernardoRheumatology Department, Centro Hospitalar e Universitário de São João, 4200-319 Porto, Portugal.ORCID 0000-0002-6224-9704
Jean-Charles GaillardDépartement Médicaments et Technologies pour la Santé (DMTS), Université Paris-Saclay, CEA, INRAE, SPI, F-30200 Bagnols-sur-Cèze, France.
Jean ArmengaudDépartement Médicaments et Technologies pour la Santé (DMTS), Université Paris-Saclay, CEA, INRAE, SPI, F-30200 Bagnols-sur-Cèze, France.ORCID 0000-0003-1589-445X
Vladimir BenesEMBL Genomics Core Facility, Meyerhofstr. 1, D-69117 Heidelberg, Germany.
Lúcia DominguesNOVA Medical Research, NOVA Medical School, NOVA University of Lisbon, 1169-056 Lisbon, Portugal.
Sara MaiaNOVA Medical Research, NOVA Medical School, NOVA University of Lisbon, 1169-056 Lisbon, Portugal.
Jaime C BrancoNOVA Medical Research, NOVA Medical School, NOVA University of Lisbon, 1169-056 Lisbon, Portugal.ORCID 0000-0001-7024-4375
Ana Varela CoelhoInstituto de Tecnologia Química e Biológica António Xavier, Nova University of Lisbon, Av. Da República, 2780-157 Oeiras, Portugal.ORCID 0000-0002-6143-4203
Fernando M Pimentel-SantosNOVA Medical Research, NOVA Medical School, NOVA University of Lisbon, 1169-056 Lisbon, Portugal.
University of Lisbon · PTCommissariat à l'Énergie Atomique et aux Énergies Alternatives · FRAdministração Regional de Saúde de Lisboa e Vale do Tejo · PTCentro Hospitalar de Vila Nova de Gaia · PTEuropean Molecular Biology Organization · DEHospitais da Universidade de Coimbra · PTHospital de São João · PTHospital Padre Américo · PTUniversidade do Porto · PT
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itself
Abstract
This study aims at identifying molecular biomarkers differentiating responders and non-responders to treatment with Tumor Necrosis Factor inhibitors (TNFi) among patients with axial spondyloarthritis (axSpA). Whole blood mRNA and plasma proteins were measured in a cohort of biologic-naïve axSpA patients (
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Molecular Profiling of Axial Spondyloarthritis Patients Reveals an Association between Innate and Adaptive Cell Populations and Therapeutic Response to Tumor Necrosis Factor Inhibitors. · full record | OpenQuestion