Evidence map›Paper›PMID 38540798›Full record

ArticleBiomolecules2024

Inhibition of Granule Cell Dispersion and Seizure Development by Astrocyte Elevated Gene-1 in a Mouse Model of Temporal Lobe Epilepsy.

Eunju Leem, Sehwan Kim, Chanchal Sharma, Youngpyo Nam, Tae Yeon Kim, Minsang Shin, Seok-Geun Lee, Jaekwang Kim, Sang Ryong Kim

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Eunju LeemBK21 FOUR KNU Creative BioResearch Group, School of Life Science, Kyungpook National University, Daegu 41566, Republic of Korea.
Sehwan KimBK21 FOUR KNU Creative BioResearch Group, School of Life Science, Kyungpook National University, Daegu 41566, Republic of Korea.
Chanchal SharmaBK21 FOUR KNU Creative BioResearch Group, School of Life Science, Kyungpook National University, Daegu 41566, Republic of Korea.
Youngpyo NamBrain Science and Engineering Institute, Kyungpook National University, Daegu 41944, Republic of Korea.
Tae Yeon KimBK21 FOUR KNU Creative BioResearch Group, School of Life Science, Kyungpook National University, Daegu 41566, Republic of Korea.
Minsang ShinDepartment of Microbiology, School of Medicine, Kyungpook National University, Daegu 41944, Republic of Korea.ORCID 0000-0001-8679-446X
Seok-Geun LeeDepartment of Biomedical Science & Technology and BioNanocomposite Research Center, Kyung Hee University, Seoul 02447, Republic of Korea.ORCID 0000-0002-0060-5777
Jaekwang KimDementia Research Group, Korea Brain Research Institute, Daegu 41062, Republic of Korea.
Sang Ryong KimBK21 FOUR KNU Creative BioResearch Group, School of Life Science, Kyungpook National University, Daegu 41566, Republic of Korea.ORCID 0000-0003-0299-1613
Kyungpook National University · KRKorea Brain Research Institute · KRKyung Hee University · KR

Funding

National Research Foundation of Korea NRF-2020R1A2C2007954 and 2021R1F1A1049849
6 · The paper itself

Abstract

Although granule cell dispersion (GCD) in the hippocampus is known to be an important feature associated with epileptic seizures in temporal lobe epilepsy (TLE), the endogenous molecules that regulate GCD are largely unknown. In the present study, we have examined whether there is any change in AEG-1 expression in the hippocampus of a kainic acid (KA)-induced mouse model of TLE. In addition, we have investigated whether the modulation of astrocyte elevated gene-1 (

Indexed as

EpilepsyEpilepsy, Temporal LobeAnimalsAstrocytesDentate GyrusHippocampusKainic AcidMembrane ProteinsMiceRNA-Binding ProteinsSeizuresKainic AcidMembrane ProteinsMtdh protein, mouseRNA-Binding Proteinsadeno-associated viral vectoradeno-associated virus 1astrocyte elevated gene-1gene therapygranule cell dispersionhippocampuskainic acidmammalian target of rapamycin complex 1seizuretemporal lobe epilepsy

Identifiers

PMID38540798
PMCPMC10968595
OpenAlexW4392983559

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.