Evidence map›Paper›PMID 38540767›Full record

ArticleBiomolecules2024

Cell-Free Mitochondrial DNA: An Upcoming Non-Invasive Tool for Diagnosis of BK Polyomavirus-Associated Nephropathy.

Luying Guo, Sulin Luo, Xingxia Wang, Nengbo Zhang, Yamei Cheng, Jia Shen, Jianghua Chen, Rending Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Luying GuoKidney Disease Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.
Sulin LuoKidney Disease Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.
Xingxia WangKidney Disease Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.
Nengbo ZhangKidney Disease Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.
Yamei ChengKidney Disease Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.
Jia ShenKidney Disease Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.
Jianghua ChenKidney Disease Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.
Rending WangKidney Disease Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.
Zhejiang University · CNNational Clinical Research Center for Digestive Diseases · CNHangzhou Center for Disease Control and Prevention · CNShanghai Clinical Research Center · CN

Funding

National Natural Science Foundation of China 82070766Science and Technology Department of Zhejiang Province 2019C03029Zhejiang Provincial Natural Science Foundation of China LQ23H050004
6 · The paper itself

Abstract

Mitochondria are essential organelles that possess their own DNA. Mitochondrial dysfunction has been revealed in many kidney diseases, including BK polyomavirus-associated nephropathy (BKPyVAN). In this study, we introduce an innovative approach for non-invasive monitoring of mitochondrial impairment through urinary donor-derived cell-free mitochondrial DNA (ddcfmtDNA), addressing the crucial challenge of BKPyVAN diagnosis. Urinary samples were collected at the time of biopsy from a total of 60 kidney transplant recipients, comprising 12 with stable function, 22 with T cell-mediated rejection, and 21 with biopsy-proven BKPyVAN. Our findings reveal that the ddcfmtDNA-to-ddcfDNA ratio exhibits superior capability in distinguishing BKPyVAN from other conditions, with a cutoff value of 4.96% (area under curve = 0.933; sensitivity: 71.4%; and specificity: 97.1%). Notably, an elevation of ddcfmtDNA levels is associated with mitochondrial damage, as visualized through electron microscopy. These results underscore the promise of non-invasive monitoring for detecting subtle mitochondrial damage and its potential utility in BKPyVAN diagnosis. Further investigations are required to advance this field of research.

Indexed as

BK VirusKidney TransplantationPolyomavirus InfectionsTumor Virus InfectionsDNA, MitochondrialGraft RejectionHumansMitochondriaDNA, MitochondrialBK polyomavirus-associated nephropathycell-free mitochondria DNAmitochondrial damage

Identifiers

PMID38540767
PMCPMC10968224
OpenAlexW4392809365

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.