Evidence map›Paper›PMID 38540766›Full record

ArticleBiomolecules2024

Hedgehog Signaling Controls Chondrogenesis and Ectopic Bone Formation via the Yap-Ihh Axis.

Qian Cong, Yingzi Yang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Qian CongDepartment of Developmental Biology, Harvard School of Dental Medicine, Harvard Stem Cell Institute, Boston, MA 02115, USA.
Yingzi YangDepartment of Developmental Biology, Harvard School of Dental Medicine, Harvard Stem Cell Institute, Boston, MA 02115, USA.
Harvard Stem Cell Institute · US

Funding

Translational Imaging and Phenotyping CoreP30AR075042 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI MARY L BOUXSEIN, PAOLA DIVIETI PAJEVIC · 2019 to 2026
$7.4M
Gas-Hedgehog signaling in intramembranous bone formation and expansionR01DE025866 · NIDCR · HARVARD MEDICAL SCHOOL · PI Yingzi Yang · 2016 to 2026
$5.3M
Molecular Mechanism of Wnt/Planar Cell Polarity SignalingR01AR070877 · NIAMS · HARVARD MEDICAL SCHOOL · PI YANG, YINGZI · 2017 to 2022
$3.0M
Mechanistic and Therapeutic Studies of Initiation and Expansion for Genetic and Acquired Heterotopic OssificationK99AR078929 · NIAMS · HARVARD MEDICAL SCHOOL · PI CONG, QIAN · 2022 to 2023
$277k
NIAMS NIH HHS AR070877NIAMS NIH HHS K99 AR078929NIAMS NIH HHS K99AR078929NIAMS NIH HHS P30 AR075042NIAMS NIH HHS R01 AR070877NIDCR NIH HHS DE025866NIDCR NIH HHS R01 DE025866
6 · The paper itself

Abstract

Fibrodysplasia ossificans progressiva (FOP) is a rare congenital disorder characterized by abnormal bone formation due to ACVR1 gene mutations. The identification of the molecular mechanisms underlying the ectopic bone formation and expansion in FOP is critical for the effective treatment or prevention of HO. Here we find that Hh signaling activation is required for the aberrant ectopic bone formation in FOP. We show that the expression of

Indexed as

Myositis OssificansOssification, HeterotopicAnimalsChondrogenesisHedgehog ProteinsMiceMutationOsteogenesisYAP-Signaling ProteinsHedgehog Proteinsihh protein, mouseYap1 protein, mouseYAP-Signaling ProteinsFOPHedgehog signalingheterotopic bone formationhuman diseasesIhhosteoblast

Identifiers

PMID38540766
PMCPMC10968511
OpenAlexW4392809341

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.