Evidence map›Paper›PMID 38540722›Full record

ArticleBiomolecules2024

Increased NLRP1 mRNA and Protein Expression Suggests Inflammasome Activation in the Dorsolateral Prefrontal and Medial Orbitofrontal Cortex in Schizophrenia.

Ena Španić Popovački, Dora Vogrinc, Heidi R Fuller, Lea Langer Horvat, Davor Mayer, Janja Kopić, Klara Pintarić, Mirjana Babić Leko, Mihaela Pravica, Željka Krsnik and 5 more

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 4 countries.

Ena Španić PopovačkiDepartment of Neuroscience, Croatian Institute for Brain Research, University of Zagreb School of Medicine, 10000 Zagreb, Croatia.
Dora VogrincDepartment of Neuroscience, Croatian Institute for Brain Research, University of Zagreb School of Medicine, 10000 Zagreb, Croatia.
Heidi R FullerWolfson Centre for Inherited Neuromuscular Disease, RJAH Orthopaedic Hospital, Oswestry SY10 7AG, UK.ORCID 0000-0002-2858-869X
Lea Langer HorvatDepartment of Neuroscience, Croatian Institute for Brain Research, University of Zagreb School of Medicine, 10000 Zagreb, Croatia.
Davor MayerDepartment of Forensic Medicine, University of Zagreb School of Medicine, 10000 Zagreb, Croatia.
Janja KopićDepartment of Neuroscience, Croatian Institute for Brain Research, University of Zagreb School of Medicine, 10000 Zagreb, Croatia.
Klara PintarićDepartment of Neuroscience, Croatian Institute for Brain Research, University of Zagreb School of Medicine, 10000 Zagreb, Croatia.
Mirjana Babić LekoDepartment of Neuroscience, Croatian Institute for Brain Research, University of Zagreb School of Medicine, 10000 Zagreb, Croatia.ORCID 0000-0003-4223-4190
Mihaela PravicaDepartment of Neuroscience, Croatian Institute for Brain Research, University of Zagreb School of Medicine, 10000 Zagreb, Croatia.
Željka KrsnikDepartment of Neuroscience, Croatian Institute for Brain Research, University of Zagreb School of Medicine, 10000 Zagreb, Croatia.ORCID 0000-0001-5238-6820
Darko MarčinkoDepartment of Psychiatry and Psychological Medicine, University Hospital Center Zagreb, 10000 Zagreb, Croatia.
Marina ŠagudDepartment of Psychiatry and Psychological Medicine, University Hospital Center Zagreb, 10000 Zagreb, Croatia.ORCID 0000-0001-9620-2181
Patrick R HofNash Family Department of Neuroscience, Center for Discovery and Innovation, and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10019, USA.
Mihovil MladinovDepartment of Psychiatry and Psychotherapy, University of Rostock, Gehlsheimer Str. 20, 18147 Rostock, Germany.ORCID 0000-0002-4886-7119
Goran ŠimićDepartment of Neuroscience, Croatian Institute for Brain Research, University of Zagreb School of Medicine, 10000 Zagreb, Croatia.ORCID 0000-0002-6339-9261
University of Zagreb · HRUniversity Hospital Centre Zagreb · HRAllen Institute for Brain Science · USRobert Jones and Agnes Hunt Orthopaedic Hospital · GBUniversity of Rostock · DE

Funding

Croatian Science Foundation IP-2019-04-3584EU Regional Development Fund KK01.1.01.0007
6 · The paper itself

Abstract

Schizophrenia is a complex mental condition, with key symptoms marked for diagnosis including delusions, hallucinations, disorganized thinking, reduced emotional expression, and social dysfunction. In the context of major developmental hypotheses of schizophrenia, notably those concerning maternal immune activation and neuroinflammation, we studied

Indexed as

SchizophreniaCerebral CortexHumansInflammasomesNLR ProteinsPrefrontal CortexPyramidal CellsInflammasomesNLRP1 protein, humanNLR ProteinsNLRP1 inflammasomepredictive processingprefrontal cortexpyramidal neuronsschizophrenia

Identifiers

PMID38540722
PMCPMC10968053
OpenAlexW4392376914

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.