Evidence map›Paper›PMID 38540682›Full record

ArticleBiomolecules2024

Antimicrobial Indole-3-Carboxamido-Polyamine Conjugates Target Bacterial Membranes and Are Antibiotic Potentiators.

Kenneth Sue, Melissa M Cadelis, Florent Rouvier, Marie-Lise Bourguet-Kondracki, Jean Michel Brunel, Brent R Copp

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Discovery of ianthelliformisamines D-G from the spongeBeilstein journal of organic chemistry · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Kenneth SueSchool of Chemical Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.ORCID 0000-0002-1477-4117
Melissa M CadelisSchool of Chemical Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.ORCID 0000-0003-3883-0109
Florent RouvierMembranes et Cibles Thérapeutiques, SSA, INSERM, Aix-Marseille Universite, 27 Bd Jean Moulin, 13385 Marseille, France.
Marie-Lise Bourguet-KondrackiLaboratoire Molécules de Communication et Adaptation des Micro-Organismes, UMR 7245 CNRS, Muséum National d'Histoire Naturelle, 57 Rue Cuvier (C.P. 54), 75005 Paris, France.
Jean Michel BrunelMembranes et Cibles Thérapeutiques, SSA, INSERM, Aix-Marseille Universite, 27 Bd Jean Moulin, 13385 Marseille, France.ORCID 0000-0002-9355-8980
Brent R CoppSchool of Chemical Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.ORCID 0000-0001-5492-5269
University of Auckland · NZInserm · FRCentre National de la Recherche Scientifique · FR

Funding

Catalyst: Seeding Dumont d'Urville NZ-France Science & Technology Support Programme 19-UOA-057-DDUWellcome Trust
6 · The paper itself

Abstract

Small molecules that can restore the action of legacy antibiotics toward drug-resistant bacteria represent an area of ongoing research interest. We have previously reported indole-3-glyoxylamido and indole-3-acetamido-polyamine conjugates that exhibit intrinsic activity toward bacterial and fungal species, and the ability to enhance the action of doxycycline toward the Gram-negative bacteria

Indexed as

Anti-Infective AgentsMethicillin-Resistant Staphylococcus aureusAnti-Bacterial AgentsBacteriaDoxycyclineHemolysisHumansIndolesMicrobial Sensitivity TestsPolyaminesPseudomonas aeruginosaStaphylococcus aureusAnti-Bacterial AgentsAnti-Infective AgentsDoxycyclineIndolesPolyaminesantibioticsantifungal agentsantimicrobialindolepolyaminepotentiatorstructure–activity relationships

Identifiers

PMID38540682
PMCPMC10967822
OpenAlexW4392084061

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.