Evidence map›Paper›PMID 38540446›Full record

ArticleGenes2024

In Vitro Low-Bortezomib Doses Induce Apoptosis and Independently Decrease the Activities of Glutathione S-Transferase and Glutathione Peroxidase in Multiple Myeloma, Taking into Account the

Szymon Zmorzynski, Sylwia Popek-Marciniec, Beata Biernacka, Aneta Szudy-Szczyrek, Sylwia Chocholska, Wojciech Styk, Joanna Czerwik-Marcinkowska, Grazyna Swiderska-Kolacz

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Szymon ZmorzynskiLaboratory of Genetics, Academy of Zamosc, 22-400 Zamosc, Poland.ORCID 0000-0002-2039-2908
Sylwia Popek-MarciniecLaboratory of Genetics, Academy of Zamosc, 22-400 Zamosc, Poland.ORCID 0000-0003-0783-6153
Beata BiernackaInstitute of Nursing and Obstetrics, Academy of Zamosc, 22-400 Zamosc, Poland.
Aneta Szudy-SzczyrekChair and Department of Haematooncology and Bone Marrow Transplantation, Medical University of Lublin, 20-059 Lublin, Poland.ORCID 0000-0003-2352-394X
Sylwia ChocholskaChair and Department of Haematooncology and Bone Marrow Transplantation, Medical University of Lublin, 20-059 Lublin, Poland.ORCID 0000-0002-5001-9258
Wojciech StykAcademic Laboratory of Psychological Tests, Medical University of Lublin, 20-059 Lublin, Poland.ORCID 0000-0003-0186-3118
Joanna Czerwik-MarcinkowskaInstitute of Biology, Jan Kochanowski University, 25-369 Kielce, Poland.ORCID 0000-0003-2019-7819
Grazyna Swiderska-KolaczInstitute of Biology, Jan Kochanowski University, 25-369 Kielce, Poland.
Medical University of Lublin · PLJan Kochanowski University · PLState Higher School of Vocational Education in Zamość · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMultiple myeloma (MM) is a malignancy derived from plasma cells. Bortezomib affects the concentration of reduced glutathione (GSH) and the activity of glutathione enzymes. The aim of our study was to analyze deletion (null/present) variants of MATERIALS AND

methodsThis study included 180 individuals (80 MM patients and 100 healthy blood donors) who were genotyped via multiplex PCR (for the

resultsBortezomib increased the number of apoptotic cells and decreased the activity of S-glutathione transferase (GST) and glutathione peroxidase (GPx). We found significant differences in GST activity between 1 nM (

conclusionsBortezomib affects the activities of GST and GPx. GST activity was associated with

Indexed as

Multiple MyelomaPolymorphism, GeneticApoptosisBortezomibGlutathioneGlutathione PeroxidaseGlutathione TransferaseHumansBortezomibGlutathioneGlutathione PeroxidaseGlutathione Transferaseapoptosisbortezomibglutathione peroxidaseglutathione reductaseglutathione S-transferasemultiple myelomareduced glutathione

Identifiers

PMID38540446
PMCPMC10970692
OpenAlexW4393046401

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.