Evidence map›Paper›PMID 38540444›Full record

ArticleGenes2024

Olfactory Receptor OR2K2 Expression in Human Choroid Plexus as a Potential Marker in Early Sporadic Alzheimer's Disease.

Victoria Cunha Alves, Joana Figueiro-Silva, Ramon Trullas, Isidre Ferrer, Eva Carro

Open access · goldAbstract read
In one paragraph

Article in Genes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 2 countries.

Victoria Cunha AlvesNeurodegenerative Diseases Group, Hospital Universitario 12 de Octubre Research Institute (imas12), 28041 Madrid, Spain.ORCID 0000-0002-3305-0165
Joana Figueiro-SilvaInstitute of Medical Genetics, University of Zurich, 8952 Zurich, Switzerland.ORCID 0000-0003-3590-1784
Ramon TrullasNetwork Center for Biomedical Research, Neurodegenerative Diseases (CIBERNED), 28029 Madrid, Spain.ORCID 0000-0001-7951-9881
Isidre FerrerNetwork Center for Biomedical Research, Neurodegenerative Diseases (CIBERNED), 28029 Madrid, Spain.ORCID 0000-0001-9888-8754
Eva CarroNetwork Center for Biomedical Research, Neurodegenerative Diseases (CIBERNED), 28029 Madrid, Spain.ORCID 0000-0002-6504-4579
Bellvitge University Hospital · ESBiomedical Research Networking Center on Neurodegenerative Diseases · ESConsejo Superior de Investigaciones Científicas · ESInstituto de Salud Carlos III · ESUniversity of Zurich · CH

Funding

Biomedical Research Networking Center on Neurodegenerative Diseases CB07/502Biomedical Research Networking Center on Neurodegenerative Diseases PI2021/03Instituto de Salud Carlos III PI2021/00679Instituto de Salud Carlos III PI22CIII/00042
6 · The paper itself

Abstract

Epithelial cells comprising the choroid plexus (CP) form a crucial barrier between the blood and the cerebrospinal fluid, thereby assuming a central position in brain homeostasis and signaling. Mounting evidence suggests that the impairment of CP function may be a significant contributor to Alzheimer's disease (AD) pathogenesis. CP function relies on the expression of specific receptors, and the potential involvement of olfactory receptors (ORs) and taste receptors (TASRs) in chemical surveillance within the CP is being investigated. Previous studies have implicated ORs and TASRs in neurodegenerative disorders like AD, although the direct evidence of their expression in the human CP remains to be established. In this study, we conducted a transcriptomic analysis encompassing eleven

Indexed as

Alzheimer DiseaseReceptors, OdorantBrainChoroid PlexusGene ExpressionHumansReceptors, OdorantAlzheimer’s diseaseautophagychoroid plexusolfactory receptorOR2K2transcriptomic

Identifiers

PMID38540444
PMCPMC10970182
OpenAlexW4393045983

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.