Evidence map›Paper›PMID 38540442›Full record

ArticleGenes2024

The Health History of First-Degree Relatives' Dyslipidemia Can Affect Preferences and Intentions following the Return of Genomic Results for Monogenic Familial Hypercholesterolemia.

Tomoharu Tokutomi, Akiko Yoshida, Akimune Fukushima, Kayono Yamamoto, Yasushi Ishigaki, Hiroshi Kawame, Nobuo Fuse, Fuji Nagami, Yoichi Suzuki, Mika Sakurai-Yageta and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 1 country.

Tomoharu TokutomiIwate Tohoku Medical Megabank Organization, Iwate Medical University, Shiwa 020-3694, Japan.ORCID 0000-0003-3001-9936
Akiko YoshidaIwate Tohoku Medical Megabank Organization, Iwate Medical University, Shiwa 020-3694, Japan.ORCID 0000-0002-9531-8008
Akimune FukushimaIwate Tohoku Medical Megabank Organization, Iwate Medical University, Shiwa 020-3694, Japan.
Kayono YamamotoDepartment of Clinical Genetics, School of Medicine, Iwate Medical University, Morioka 020-8505, Japan.
Yasushi IshigakiIwate Tohoku Medical Megabank Organization, Iwate Medical University, Shiwa 020-3694, Japan.ORCID 0000-0003-2479-5752
Hiroshi KawameTohoku Medical Megabank Organization, Tohoku University, Sendai 980-8573, Japan.ORCID 0000-0001-5661-3525
Nobuo FuseTohoku Medical Megabank Organization, Tohoku University, Sendai 980-8573, Japan.
Fuji NagamiTohoku Medical Megabank Organization, Tohoku University, Sendai 980-8573, Japan.
Yoichi SuzukiTohoku Medical Megabank Organization, Tohoku University, Sendai 980-8573, Japan.
Mika Sakurai-YagetaTohoku Medical Megabank Organization, Tohoku University, Sendai 980-8573, Japan.ORCID 0000-0001-5606-3324
Akira UrunoTohoku Medical Megabank Organization, Tohoku University, Sendai 980-8573, Japan.
Kichiya SuzukiTohoku Medical Megabank Organization, Tohoku University, Sendai 980-8573, Japan.
Kozo TannoIwate Tohoku Medical Megabank Organization, Iwate Medical University, Shiwa 020-3694, Japan.ORCID 0000-0002-1264-0684
Hideki OhmomoIwate Tohoku Medical Megabank Organization, Iwate Medical University, Shiwa 020-3694, Japan.ORCID 0000-0002-3524-6524
Atsushi ShimizuIwate Tohoku Medical Megabank Organization, Iwate Medical University, Shiwa 020-3694, Japan.
Masayuki YamamotoTohoku Medical Megabank Organization, Tohoku University, Sendai 980-8573, Japan.ORCID 0000-0002-9073-9436
Makoto SasakiIwate Tohoku Medical Megabank Organization, Iwate Medical University, Shiwa 020-3694, Japan.
Iwate Medical University · JPTohoku University · JP

Funding

Japan Agency for Medical Research and Development JP20km0105001Japan Agency for Medical Research and Development JP20km0105003
6 · The paper itself

Abstract

Genetic testing is key in modern healthcare, particularly for monogenic disorders such as familial hypercholesterolemia. This Tohoku Medical Megabank Project study explored the impact of first-degree relatives' dyslipidemia history on individual responses to familial hypercholesterolemia genomic results. Involving 214 participants and using Japan's 3.5KJPN genome reference panel, the study assessed preferences and intentions regarding familial hypercholesterolemia genetic testing results. The data revealed a significant inclination among participants with a family history of dyslipidemia to share their genetic test results, with more than 80% of participants intending to share positive results with their partners and children and 98.1% acknowledging the usefulness of positive results for personal health management. The study underscores the importance of family health history in genetic-testing perceptions, highlighting the need for family-centered approaches in genetic counseling and healthcare. Notable study limitations include the regional scope and reliance on questionnaire data. The study results emphasize the association between family health history and genetic-testing attitudes and decisions.

Indexed as

Hyperlipoproteinemia Type IIIntentionChildGenetic CounselingGenetic TestingGenomicsHumansfamilial hypercholesterolemiafamily health historygenetic-testing preferencesinformation sharingpersonalized healthcare

Identifiers

PMID38540442
PMCPMC10970353
OpenAlexW4393046132

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.