Evidence map›Paper›PMID 38540370›Full record

ArticleGenes2024

Novel Pathogenic Variants Leading to Sporadic Amyotrophic Lateral Sclerosis in Greek Patients.

Ouliana Ivantsik, Anne John, Kyriaki Kydonopoulou, Konstantinos Mitropoulos, Spyridon Gerou, Bassam R Ali, George P Patrinos

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. TDP-43: [GU]-ardian of the transcriptome.Molecular neurodegeneration · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Ouliana IvantsikLaboratory of Pharmacogenomics and Individualized Therapy, Division of Pharmacology and Biosciences, Department of Pharmacy, School of Health Sciences, University of Patras, 26504 Rion, Greece.
Anne JohnDepartment of Genetics and Genomics, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain P.O. Box 15551, United Arab Emirates.
Kyriaki KydonopoulouANALYSI Biomedical Laboratories S.A., 54623 Thessaloniki, Greece.
Konstantinos MitropoulosDepartment of Histology and Embryology, School of Medicine, National and Kapodistrian University of Athens, 10679 Athens, Greece.
Spyridon GerouANALYSI Biomedical Laboratories S.A., 54623 Thessaloniki, Greece.
Bassam R AliDepartment of Genetics and Genomics, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain P.O. Box 15551, United Arab Emirates.ORCID 0000-0003-1306-6618
George P PatrinosLaboratory of Pharmacogenomics and Individualized Therapy, Division of Pharmacology and Biosciences, Department of Pharmacy, School of Health Sciences, University of Patras, 26504 Rion, Greece.ORCID 0000-0002-0519-7776
Alexander Fleming Biomedical Sciences Research Center · GRUnited Arab Emirates University · AEUniversity of Patras · GRNational and Kapodistrian University of Athens · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Amyotrophic lateral sclerosis (ALS) is a rapidly progressive disease that affects motor neurons, leading to paralysis and death usually 3-5 years after the onset of symptoms. The investigation of both sporadic and familial ALS highlighted four main genes that contribute to the pathogenesis of the disease:

Indexed as

Amyotrophic Lateral SclerosisGreeceHumansMutationSuperoxide Dismutase-1Superoxide Dismutase-1amyotrophic lateral sclerosisFUSgeneticsgenomic variantsSOD1sporadic ALSTARDBP

Identifiers

PMID38540370
PMCPMC10970271
OpenAlexW4392234214

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.