Evidence map›Paper›PMID 38540368›Full record

ArticleGenes2024

Identification and Analysis of Axolotl Homologs for Proteins Implicated in Human Neurodegenerative Proteinopathies.

Lucas M James, Zachary Strickland, Noah Lopez, Jessica L Whited, Malcolm Maden, Jada Lewis

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Lucas M JamesDepartment of Neuroscience, University of Florida, Gainesville, FL 32610, USA.ORCID 0000-0003-0499-9299
Zachary StricklandDepartment of Neuroscience, University of Florida, Gainesville, FL 32610, USA.ORCID 0000-0001-5210-5734
Noah LopezDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.
Jessica L WhitedDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.
Malcolm MadenDepartment of Biology and UF Genetics Institute, University of Florida, Gainesville, FL 32611, USA.
Jada LewisDepartment of Neuroscience, University of Florida, Gainesville, FL 32610, USA.ORCID 0000-0003-0004-6597
University of Florida · USBroad Institute · US

Funding

Elucidating factors that modulate tauopathy and cellular degeneration to guide therapeutic developmentRF1AG064914 · NIA · UNIVERSITY OF FLORIDA · PI GOLDE, TODD E, LEWIS, JADA M · 2019 to 2019
$2.5M
IDENTIFYING ROADBLOCKS TO LIMB REGENERATIONR01HD095494 · NICHD · HARVARD UNIVERSITY · PI WHITED, JESSICA L. · 2019 to 2023
$1.9M
NIA NIH HHS 1RF1AG064914NIA NIH HHS RF1 AG064914NICHD NIH HHS R01 HD095494
6 · The paper itself

Abstract

Neurodegenerative proteinopathies such as Alzheimer's Disease are characterized by abnormal protein aggregation and neurodegeneration. Neuroresilience or regenerative strategies to prevent neurodegeneration, preserve function, or restore lost neurons may have the potential to combat human proteinopathies; however, the adult human brain possesses a limited capacity to replace lost neurons. In contrast, axolotls (

Indexed as

Alzheimer DiseaseNeurodegenerative DiseasesProteostasis DeficienciesAdultAmbystoma mexicanumAmyloid Precursor Protein SecretasesAnimalsAspartic Acid EndopeptidasesHumanstau ProteinsAmyloid Precursor Protein SecretasesAspartic Acid Endopeptidasestau Proteinsaxolotlneurodegenerationproteinopathyproteinsregeneration

Identifiers

PMID38540368
PMCPMC10969905
OpenAlexW4392238054

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.