Evidence map›Paper›PMID 38540283›Full record

ArticleBiomedicines2024

Can Repetitive Transcranial Magnetic Stimulation (rTMS) Promote Neurogenesis and Axonogenesis in Subacute Human Ischemic Stroke?

Manuela De Michele, Paola Piscopo, Matteo Costanzo, Svetlana Lorenzano, Alessio Crestini, Roberto Rivabene, Valeria Manzini, Luca Petraglia, Marta Iacobucci, Irene Berto and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Manuela De MicheleEmergency Department, Stroke Unit, Policlinico Umberto I Hospital, Sapienza University, 00161 Rome, Italy.
Paola PiscopoDepartment of Neuroscience, Italian National Institute of Health, 00161 Rome, Italy.ORCID 0000-0002-0693-4969
Matteo CostanzoDepartment of Neuroscience, Italian National Institute of Health, 00161 Rome, Italy.
Svetlana LorenzanoDepartment of Human Neurosciences, Sapienza University, 00185 Rome, Italy.
Alessio CrestiniDepartment of Neuroscience, Italian National Institute of Health, 00161 Rome, Italy.ORCID 0000-0003-0787-7799
Roberto RivabeneDepartment of Neuroscience, Italian National Institute of Health, 00161 Rome, Italy.ORCID 0000-0002-3687-969X
Valeria ManziniDepartment of Neuroscience, Italian National Institute of Health, 00161 Rome, Italy.ORCID 0000-0002-2224-3594
Luca PetragliaEmergency Department, Stroke Unit, Policlinico Umberto I Hospital, Sapienza University, 00161 Rome, Italy.
Marta IacobucciNeuroradiology Unit, Department of Human Neurosciences, Policlinico Umberto I Hospital, Sapienza University, 00161 Rome, Italy.ORCID 0000-0002-3911-3278
Irene BertoDepartment of Human Neurosciences, Sapienza University, 00185 Rome, Italy.
Oscar Gaetano SchiavoEmergency Department, Stroke Unit, Policlinico Umberto I Hospital, Sapienza University, 00161 Rome, Italy.
Antonella ConteDepartment of Human Neurosciences, Sapienza University, 00185 Rome, Italy.ORCID 0000-0002-6338-2961
Daniele BelvisiDepartment of Human Neurosciences, Sapienza University, 00185 Rome, Italy.
Alfredo BerardelliDepartment of Human Neurosciences, Sapienza University, 00185 Rome, Italy.
Danilo ToniDepartment of Human Neurosciences, Sapienza University, 00185 Rome, Italy.ORCID 0000-0003-2735-8427
Sapienza University of Rome · ITPoliclinico Umberto I · ITIstituto Neurologico Mediterraneo · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIschemic stroke may trigger neuroplastic changes via proliferation, migration towards the lesion, and differentiation of neuroprogenitor cells into mature neurons. Repetitive Transcranial Magnetic Stimulation (rTMS) may promote brain plasticity. This study aimed to assess rTMS's effect on post-stroke endogenous neuroplasticity by dosing plasma miRs 17~92, Netrin-1, Sema3A, and BDNF.

methodsIn this case-controlled study, we randomized 19 ischemic stroke patients within five days from symptoms onset (T0) to neuronavigated-rTMS or sham stimulation. Stimulation was applied on the stroke hemisphere daily between the 7th and 14th day from stroke onset. Blood samples were collected at T0, before the first rTMS section (T7), and at the end of the last rTMS session (T14). Five healthy controls were also enrolled in this study.

resultsOf 19 patients, 10 received rTMS and 9 sham stimulation. Compared with the sham group, in the rTMS group, plasma levels of miRs17~92 and Ntn-1 significantly increased whereas Sema3A levels tended to decrease. In multivariate linear regression analyses, rTMS was independently related to Ntn-1 and miR-25 levels at T14.

conclusionsWe found an association between rTMS and neurogenesis/axonogenesis biomarker enhancement. Our preliminary data suggest that rTMS may positively interfere with natural endogenous plasticity phenomena of the post-ischemic human brain.

Indexed as

axonogenesishumansischemiaMiR25miRNANetrin-1neurogenesisrTMSsemaphorinstroke

Identifiers

PMID38540283
PMCPMC10968490
OpenAlexW4392916794

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.