Evidence map›Paper›PMID 38540246›Full record

ArticleBiomedicines2024

Immune Analysis Using Vitreous Optical Coherence Tomography Imaging in Rats with Steroid-Induced Glaucoma.

Maria J Rodrigo, Manuel Subías, Alberto Montolío, Teresa Martínez-Rincón, Alba Aragón-Navas, Irene Bravo-Osuna, Luis E Pablo, Jose Cegoñino, Rocío Herrero-Vanrell, Elena Garcia-Martin and 1 more

Open access · goldAbstract read
In one paragraph

Article in Biomedicines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Maria J RodrigoDepartment of Ophthalmology, Miguel Servet University Hospital, 50009 Zaragoza, Spain.ORCID 0000-0002-4009-3075
Manuel SubíasDepartment of Ophthalmology, Miguel Servet University Hospital, 50009 Zaragoza, Spain.ORCID 0000-0002-2344-016X
Alberto MontolíoBiomaterials Group, Aragon Engineering Research Institute (I3A), University of Zaragoza, 50018 Zaragoza, Spain.ORCID 0000-0001-7248-4399
Teresa Martínez-RincónDepartment of Ophthalmology, Miguel Servet University Hospital, 50009 Zaragoza, Spain.ORCID 0000-0002-8891-0417
Alba Aragón-NavasInnovation, Therapy and Pharmaceutical Development in Ophthalmology (InnOftal) Research Group, UCM 920415, Department of Pharmaceutics and Food Technology, Faculty of Pharmacy, Complutense University of Madrid, 28040 Madrid, Spain.ORCID 0000-0002-7466-8914
Irene Bravo-OsunaInnovation, Therapy and Pharmaceutical Development in Ophthalmology (InnOftal) Research Group, UCM 920415, Department of Pharmaceutics and Food Technology, Faculty of Pharmacy, Complutense University of Madrid, 28040 Madrid, Spain.ORCID 0000-0003-3133-7872
Luis E PabloDepartment of Ophthalmology, Miguel Servet University Hospital, 50009 Zaragoza, Spain.
Jose CegoñinoBiomaterials Group, Aragon Engineering Research Institute (I3A), University of Zaragoza, 50018 Zaragoza, Spain.
Rocío Herrero-VanrellInnovation, Therapy and Pharmaceutical Development in Ophthalmology (InnOftal) Research Group, UCM 920415, Department of Pharmaceutics and Food Technology, Faculty of Pharmacy, Complutense University of Madrid, 28040 Madrid, Spain.
Elena Garcia-MartinDepartment of Ophthalmology, Miguel Servet University Hospital, 50009 Zaragoza, Spain.ORCID 0000-0001-6258-2489
Amaya Pérez Del PalomarBiomaterials Group, Aragon Engineering Research Institute (I3A), University of Zaragoza, 50018 Zaragoza, Spain.ORCID 0000-0003-0669-777X
Universidad de Zaragoza · ESUniversidad Complutense de Madrid · ES

Funding

Instituto de Salud Carlos III Grants M17/00213, JR22/00057, PI17/01726, PI17/01946 and PI20/00437Ministerio de Asuntos Económicos y Transformación Digital MAT2017-83858-C2-1, MAT2017-83858-C2-2, MCIN/AEI/ 10.13039/501100011033. PID2020-113281RB-C2-1 and PID2020-113281RB-C2-2, and co-funded by the European Union ERDR A way of making Europe
6 · The paper itself

Abstract

Glaucoma is a multifactorial pathology involving the immune system. The subclinical immune response plays a homeostatic role in healthy situations, but in pathological situations, it produces imbalances. Optical coherence tomography detects immune cells in the vitreous as hyperreflective opacities and these are subsequently characterised by computational analysis. This study monitors the changes in immunity in the vitreous in two steroid-induced glaucoma (SIG) animal models created with drug delivery systems (microspheres loaded with dexamethasone and dexamethasone/fibronectin), comparing both sexes and healthy controls over six months. SIG eyes tended to present greater intensity and a higher number of vitreous opacities (

Indexed as

animal modelsglaucomainflammationoptical coherence tomographyvitreous body

Identifiers

PMID38540246
PMCPMC10967960
OpenAlexW4392746058

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.