ReviewAnimals : an open access journal from MDPI2024
The Complex Interplay of Insulin Resistance and Metabolic Inflammation in Transition Dairy Cows.
Review in Animals : an open access journal from MDPI, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 22 citations in OpenAlex.
- Milk extracellular vesicles reveal insulin resistance status in peripartum dairy cows.The veterinary quarterly · 2026Article
- Analytical Technologies for Milk Component Analysis: A Review of Progress and Challenges.Foods (Basel, Switzerland) · 2026Review
- Delayed ovulation in cattle: Physiological mechanisms, diagnostic approaches, and reproductive management strategies.Veterinary world · 2026Article
- Intravenous administration of walnut leaf extract attenuates oxidative stress and improves insulin sensitivity and adipose tissue metabolism in feed-restricted fat-tailed ewes.Veterinary and animal science · 2026Article
- Effect of the Use of Bovine Appeasing Substance on Immunological, Metabolic, and Oxidative Parameters of Postpartum Dairy Cows: Modulation of the Stress Axis.Animals : an open access journal from MDPI · 2026Article
- Article
- Immunometabolic-uterine-ovarian interactions and flushing therapy in dairy cows: a narrative review.Veterinary world · 2026Review
- Liver and Skeletal Muscle Metabolome Characterization in Peripartal Dairy Cows Fed Rumen-Protected Methionine or Rumen-Protected Choline.Animals : an open access journal from MDPI · 2026Article
- Increased maternal non-esterified fatty acid concentrations during late gestation impair adipose tissue development and metabolic function in Holstein offspring calves.Journal of animal science · 2026Article
- Identification of reproductive and molecular biomarkers associated with clinical metritis in dromedary camels (Frontiers in veterinary science · 2026Article
- Routine milk records reveal novel two-way interactions shaping ketosis risk in German dairy cows.PloS one · 2026Article
- Effects of Dietary Supplementation with Dihydromyricetin on Hindgut Microbiota and Metabolite Profiles in Dairy Cows.Microorganisms · 2025Article
- Relation Between Inflammatory Parameters and Insulin Resistance Indices in Cows During Early Lactation.Metabolites · 2025Article
- Preparturient Oral Selenitetriglycerides Supplementation Elevates Erythrocyte Glutathione Peroxidase Activity and Modulates HepaticInternational journal of molecular sciences · 2025Article
- Effects of monensin, phytogenic compounds, or a blend of feed additives on health and performance of dairy cows.Translational animal science · 2025Article
- Mechanism and application of yeast and its culture in regulating intestinal antioxidant defense in ruminants.Frontiers in veterinary science · 2025Review
- Bovine adipose mitochondrial adaptation and a potential lactate-ketone toggle in early lactation.Frontiers in veterinary science · 2025Article
- Welfare indicators in cattle farming in the face of heat stress: a review in climate change scenarios.Frontiers in veterinary science · 2025Article
- Glabridin ameliorates oxidative stress and inflammation in a bovine intestinal cell line and a colitis mouse model.Iranian journal of veterinary research · 2025Article
- Glucose Metabolism-Modifying Natural Materials for Potential Feed Additive Development.Pharmaceutics · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
During the transition period, dairy cows exhibit heightened energy requirements to sustain fetal growth and lactogenesis. The mammary gland and the growing fetus increase their demand for glucose, leading to the mobilization of lipids to support the function of tissues that can use fatty acids as energy substrates. These physiological adaptations lead to negative energy balance, metabolic inflammation, and transient insulin resistance (IR), processes that are part of the normal homeorhetic adaptations related to parturition and subsequent lactation. Insulin resistance is characterized by a reduced biological response of insulin-sensitive tissues to normal physiological concentrations of insulin. Metabolic inflammation is characterized by a chronic, low-level inflammatory state that is strongly associated with metabolic disorders. The relationship between IR and metabolic inflammation in transitioning cows is intricate and mutually influential. On one hand, IR may play a role in the initiation of metabolic inflammation by promoting lipolysis in adipose tissue and increasing the release of free fatty acids. Metabolic inflammation, conversely, triggers inflammatory signaling pathways by pro-inflammatory cytokines, thereby leading to impaired insulin signaling. The interaction of these factors results in a harmful cycle in which IR and metabolic inflammation mutually reinforce each other. This article offers a comprehensive review of recent advancements in the research on IR, metabolic inflammation, and their intricate interrelationship. The text delves into multiple facets of physiological regulation, pathogenesis, and their consequent impacts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.